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These brands contain the same active ingredient (Tolfenamic Acid). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Tolnil
Other strengths and forms by OSL Pharma Ltd.
Indications & Uses
Pharmacology
Tolfenamic acid (N-(2-methyl-3-chlorophenyl) anthranilic acid) belongs to the fenamate group. It is a strong inhibitor of the cyclooxygenase enzyme, so it blocks the making of important inflammatory mediators such as thromboxane (TX) B2 and prostaglandin (PG) E2. Prostaglandins are what cause swelling, pain and inflammation in these conditions. The medicine works in two ways. Besides stopping prostaglandin synthesis, it also acts directly against prostaglandin receptors.
Pharmacokinetic properties
Absorption: Tolfenamic acid is readily absorbed from the GI tract. Peak plasma concentration is reached in 60 to 90 min. Bioavailability is 85%.
Distribution: About 99% of the drug binds to plasma protein. Plasma half-life is 2 hours.
Metabolism: The medicine is metabolised in the liver. Tolfenamic acid undergoes enterohepatic circulation.
Excretion: Most of it leaves the body in the urine (90%), and the rest is excreted in faeces.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Tolfenamic acid is taken at the following adult doses. For acute migraine attacks, the usual dose is 200 mg when symptoms first appear. If needed, this can be repeated once after 1 to 2 hours. For mild to moderate pain, the dose is 100 to 200 mg three times a day.
If you have kidney problems, your doctor may need to adjust the dose. In severe renal impairment, tolfenamic acid should be avoided. A dosage regimen for children has not yet been established.
Take tolfenamic acid with food. Drink water during or straight after your meal.
Side Effects
Side effects are generally uncommon and can include inflammation of the lung tissue (alveolitis), liver damage, pancreatitis, pulmonary eosinophilia, Stevens-Johnson syndrome, angioedema, blood disorders, depression, diarrhea, dizziness, drowsiness, painful urination, euphoria, gastrointestinal bleeding, gastrointestinal discomfort, hallucination, insomnia, malaise, nausea, hearing disturbances, rash, visual disturbances, vertigo, and raised blood pressure. In case of overdose, symptoms may include headache, nausea, vomiting, gastrointestinal bleeding, drowsiness, dizziness, and occasionally convulsions. Significant poisoning may lead to acute kidney failure and liver damage.
Cautions & Contraindications
Warnings & Precautions
Take extra care with tolfenamic acid if you have asthma or bronchospasm, a bleeding disorder, heart or blood vessel disease, a peptic ulcer, high blood pressure, a liver infection, or problems with your heart or kidneys. Older people also need to be watched more closely. If you have pain or burning when passing urine, your doctor may suggest drinking more water or lowering the dose.
Contraindications
Tolfenamic acid should not be used if you have bleeding in your stomach or intestines right now, or an active ulcer there. It should also be avoided if you have had stomach or intestinal bleeding before that was linked to earlier NSAID treatment, or any past bleeding from the gut. Do not take it if a hole (perforation) formed in your gut after earlier NSAID use, or if you keep getting stomach or intestinal ulcers. People with severe heart failure should not use it either.
Pregnancy & Breastfeeding
This medicine is not usually recommended during pregnancy unless a doctor considers it essential, and it must not be given during the third trimester. NSAIDs can pass into breast milk in very small amounts, so they should be avoided during breastfeeding if possible.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An overdose of tolfenamic acid can cause headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding and diarrhoea. Some people become excited, while others feel drowsy or dizzy, or go into a coma. Tinnitus, fainting and convulsions can also occur.
In significant poisoning, acute renal failure and liver damage are possible. Treatment is symptomatic, meaning patients are treated for whatever symptoms they develop.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Tolfenamic Acid in a cool, dry place, away from light. Keep it out of the reach of children.
Drug Interactions
Common questions about Tolnil 200 mg
What is Tolnil 200 mg Tablet?
Tolnil 200 mg Tablet is a medicine that contains Tolfenamic Acid. It is made by OSL Pharma Ltd. It belongs to the Drugs used for Rheumatoid Arthritis group of medicines.
What is Tolnil used for?
Tolnil is used for: Migraine, Headache, Pain, Fever.
What are the side effects of Tolnil?
Side effects are generally uncommon and can include inflammation of the lung tissue (alveolitis), liver damage, pancreatitis, pulmonary eosinophilia, Stevens-Johnson syndrome, angioedema, blood disorders, depression, diarrhea, dizziness, drowsiness, painful urination, euphoria, gastrointestinal bleeding, gastrointestinal discomfort, hallucination, insomnia, malaise, nausea, hearing disturbances, rash, visual disturbances, vertigo, and raised blood pressure. In case of overdose, symptoms may include headache, nausea, vomiting, gastrointestinal bleeding, drowsiness, dizziness, and occasionally convulsions.
Can I take Tolnil during pregnancy or while breastfeeding?
This medicine is not usually recommended during pregnancy unless a doctor considers it essential, and it must not be given during the third trimester. NSAIDs can pass into breast milk in very small amounts, so they should be avoided during breastfeeding if possible. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Tolnil?
An overdose of tolfenamic acid can cause headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding and diarrhoea. Some people become excited, while others feel drowsy or dizzy, or go into a coma. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Tolnil?
Store Tolfenamic Acid in a cool, dry place, away from light. Keep it out of the reach of children.
Can I take other medicines with Tolnil?
Some medicines can interact with Tolfenamic Acid, for example: Methotrexate, Magnesium Hydroxide, Tacrolimus, Metoclopramide, Magnesium, Cyclosporine. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Achnil by Desh Pharmaceuticals Ltd. has the same ingredient and strength for ৳8.00 per unit, compared with ৳10.00 for Tolnil. Ask your doctor or pharmacist before switching.
Do I need a prescription for Tolnil?
Tolnil is a prescription (Rx) medicine. Take it as your doctor advises.