Indications
Terazosin Hydrochloride is used as single therapy to relieve the signs and symptoms of benign prostatic hyperplasia (BPH). It is also used to treat hypertension.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Terazosin is selective for alpha-1-adrenoceptors, but it doesn't act on their individual subtypes separately. Blocking these receptors relaxes the smooth muscle in blood vessels and in the prostate, which lowers blood pressure and improves urinary flow. Smooth muscle cells make up roughly 40% of the volume of the prostate, so when they relax, the pressure on the urethra falls.
Catecholamines have also been shown to induce factors responsible for mitogenesis, and alpha-1-adrenergic receptor blockers inhibit this effect. A final long term mechanism, shared by terazosin and other alpha-1-adrenergic receptor blockers, is the induction of apoptosis of prostate cells. Treatment with terazosin enhances the expression of transforming growth factor beta-1 (TGF-beta1), which upregulates p27kip1, and the caspase cascade.
Pregnancy & Breastfeeding
Nobody has established that Terazosin is safe in pregnancy, so it isn't recommended during pregnancy. The exception is when the possible benefit justifies the possible risk to the mother and the fetus.
It isn't known whether Terazosin passes into breast milk. Many drugs do, so a nursing mother should be given Terazosin with caution.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.