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Indications & Uses
Terazosin Hydrochloride is used as single therapy to relieve the signs and symptoms of benign prostatic hyperplasia (BPH). It is also used to treat hypertension.
Pharmacology
Terazosin is selective for alpha-1-adrenoceptors, but it doesn't act on their individual subtypes separately. Blocking these receptors relaxes the smooth muscle in blood vessels and in the prostate, which lowers blood pressure and improves urinary flow. Smooth muscle cells make up roughly 40% of the volume of the prostate, so when they relax, the pressure on the urethra falls.
Catecholamines have also been shown to induce factors responsible for mitogenesis, and alpha-1-adrenergic receptor blockers inhibit this effect. A final long term mechanism, shared by terazosin and other alpha-1-adrenergic receptor blockers, is the induction of apoptosis of prostate cells. Treatment with terazosin enhances the expression of transforming growth factor beta-1 (TGF-beta1), which upregulates p27kip1, and the caspase cascade.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Benign Prostatic Hyperplasia
Initial dose: 1 mg at bedtime is the starting dose for all patients, and this dose should not be exceeded. Subsequent dose: the dose is increased slowly until the desired response is reached. The usual recommended dose range is 5 to 10 mg taken once a day.
Hypertension
Initial dose: 1 mg at bedtime is the starting dose for all patients, and this dose should not be exceeded. Subsequent dose: the dose is increased slowly until the desired response is reached. The usual recommended dose range is 2 to 10 mg taken once a day.
Side Effects
Postural hypotension is the side effect reported most often with terazosin hydrochloride. Dizziness, lack of energy and peripheral oedema have also been reported, as have urinary frequency and priapism.
Cautions & Contraindications
Warnings & Precautions
The first dose of Terazosin Hydrochloride may cause low blood pressure, usually within 30 to 90 minutes. So the first dose should be taken on going to bed at night. Take care when Terazosin Hydrochloride is given with other antihypertensive medicines, because this can lead to a significant fall in blood pressure. If Terazosin Hydrochloride is added to a diuretic or another antihypertensive, the dose may need to be reduced and then titrated again. Patients should be warned to avoid situations such as driving and hazardous tasks after starting Terazosin Hydrochloride, since fainting (syncope) could cause injury.
Contraindications
Terazosin should not be given to anyone who is known to be hypersensitive to Terazosin or to drugs similar to it (its analogues).
Pregnancy & Breastfeeding
Nobody has established that Terazosin is safe in pregnancy, so it isn't recommended during pregnancy. The exception is when the possible benefit justifies the possible risk to the mother and the fetus.
It isn't known whether Terazosin passes into breast milk. Many drugs do, so a nursing mother should be given Terazosin with caution.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An acute overdose of Terazosin Hydrochloride can cause a sudden fall in blood pressure (acute hypotension), so supporting the cardiovascular system comes first. Keeping the patient lying flat on their back (supine) can help bring blood pressure back up and return the heart rate to normal. At the same time, the plasma volume may need to be expanded, and a noradrenergic vasopressor may also be needed.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Terazosin Hydrochloride below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Common questions about Prostol 2 mg
What is Prostol 2 mg Capsule?
Prostol 2 mg Capsule is a medicine that contains Terazosin Hydrochloride. It is made by Drug International Unani Ltd. It belongs to the Alpha adrenoceptor blocking drugs group of medicines.
What is Prostol used for?
Terazosin Hydrochloride is used as single therapy to relieve the signs and symptoms of benign prostatic hyperplasia (BPH). It is also used to treat hypertension.
What are the side effects of Prostol?
Postural hypotension is the side effect reported most often with terazosin hydrochloride. Dizziness, lack of energy and peripheral oedema have also been reported, as have urinary frequency and priapism.
Can I take Prostol during pregnancy or while breastfeeding?
Nobody has established that Terazosin is safe in pregnancy, so it isn't recommended during pregnancy. The exception is when the possible benefit justifies the possible risk to the mother and the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Prostol?
An acute overdose of Terazosin Hydrochloride can cause a sudden fall in blood pressure (acute hypotension), so supporting the cardiovascular system comes first. Keeping the patient lying flat on their back (supine) can help bring blood pressure back up and return the heart rate to normal. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Prostol?
Store Terazosin Hydrochloride below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Is there a cheaper medicine with the same ingredient?
Prostol is already among the lowest-priced brands of Terazosin Hydrochloride at this strength.
Do I need a prescription for Prostol?
Prostol is a prescription (Rx) medicine. Take it as your doctor advises.