Indications
Tenofovir Disoproxil is used together with other antiretroviral medicines to treat HIV-1 infection. It is also used to treat chronic hepatitis B in adults.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Mechanism of Action: Tenofovir blocks the activity of HIV reverse transcriptase by competing with the natural substrate, deoxyadenosine 5-triphosphate. These drugs are analogues of the naturally occurring deoxynucleotides that are needed to make viral DNA, and they compete with those natural deoxynucleotides to get built into the growing viral DNA chain.
Pharmacokinetics: Tenofovir is a water soluble diester prodrug of the active ingredient Tenofovir. Its oral bioavailability is approximately 25%. When HIV-1 infected subjects took a single dose of Tenofovir 245 mg by mouth in the fasted state, maximum serum concentrations (Cmax) were reached in 1.0 10.4 hrs. The Cmax and AUC values are 0.30 0.09 ug/mL and 2.29 + 0.69 ug hr/mL, respectively. Protein binding is very low, with <0.7% bound to human plasma proteins and <7.2% to serum proteins. The half life is approximately 17 hours. Tenofovir leaves the body through a combination of glomerular filtration and active tubular secretion.
Pregnancy & Breastfeeding
Tenofovir Disoproxil is in pregnancy category B. There are no adequate and well-controlled studies in pregnant women, so Tenofovir should be used during pregnancy only if it is clearly needed. The Centers for Disease Control and Prevention recommend that mothers infected with HIV-1 not breastfeed their infants, to avoid the risk of passing HIV-1 on after birth.
Pediatric Use
For treating HIV-1 in patients 12 years of age and older with a body weight greater than or equal to 35 kg, the dose is a 245 mg Tenofovir tablet taken orally once daily.
Geriatric Use
Clinical trials of Tenofovir did not include enough people aged 65 and over to show whether they respond differently from younger people. In general, the dose for an elderly patient should be chosen with caution, because decreased hepatic, renal or cardiac function is more frequent in this age group, and so are other diseases and other drug therapy.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.