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Same active ingredient — pay up to 12% less
These brands contain the same active ingredient (Tenofovir Disoproxil). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Tenofovir Disoproxil is used together with other antiretroviral medicines to treat HIV-1 infection. It is also used to treat chronic hepatitis B in adults.
Pharmacology
Mechanism of Action: Tenofovir blocks the activity of HIV reverse transcriptase by competing with the natural substrate, deoxyadenosine 5-triphosphate. These drugs are analogues of the naturally occurring deoxynucleotides that are needed to make viral DNA, and they compete with those natural deoxynucleotides to get built into the growing viral DNA chain.
Pharmacokinetics: Tenofovir is a water soluble diester prodrug of the active ingredient Tenofovir. Its oral bioavailability is approximately 25%. When HIV-1 infected subjects took a single dose of Tenofovir 245 mg by mouth in the fasted state, maximum serum concentrations (Cmax) were reached in 1.0 10.4 hrs. The Cmax and AUC values are 0.30 0.09 ug/mL and 2.29 + 0.69 ug hr/mL, respectively. Protein binding is very low, with <0.7% bound to human plasma proteins and <7.2% to serum proteins. The half life is approximately 17 hours. Tenofovir leaves the body through a combination of glomerular filtration and active tubular secretion.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The dose has to be matched to each patient's needs, both in size and in how often it is given. Tenofovir disoproxil 245 mg tablets are taken by mouth once daily, with or without food.
Recommended dose in adults: for treating HIV-1 or chronic hepatitis B, the dose is one 245 mg Tenofovir tablet once daily, taken by mouth, with or without food. In chronic hepatitis B, the best length of treatment is not known.
Recommended dose in pediatric patients (12 years of age and older and greater than or equal to 35 kg): for treating HIV-1 in pediatric patients 12 years of age and older with a body weight greater than or equal to 35 kg, the dose is one 245 mg Tenofovir tablet once daily, taken by mouth, with or without food.
Side Effects
Tenofovir Disoproxil can cause side effects, as any medicine can. Most of them are minor and need no treatment, or they can be dealt with easily by you or your doctor. Headache, diarrhea, nausea and weakness seem to be the most common ones. Indigestion or heartburn, chest pain and drowsiness are also possible. Most side effects of Tenofovir Disoproxil are minor, but some need to be reported to your doctor immediately. These are high cholesterol or triglycerides, kidney problems, depression and anxiety.
Cautions & Contraindications
Warnings & Precautions
Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with nucleoside analogs, Tenofovir Disoproxil among them, when used together with other antiretrovirals. Most of these cases were in women. Exacerbation of hepatitis after stopping treatment: stopping anti-HBV therapy, including Tenofovir Disoproxil, may be linked with severe acute exacerbations of hepatitis. Patients infected with HBV who stop Tenofovir Disoproxil should be watched closely, with both clinical and laboratory follow-up, for at least several months after stopping. New onset or worsening renal impairment: the kidney is the main route by which Tenofovir Disoproxil leaves the body. Renal impairment has been reported with its use, including cases of acute renal failure and Fanconi syndrome (renal tubular injury with severe hypophosphatemia). Coadministration with other products: Tenofovir Disoproxil should not be used with fixed-dose combination products that contain Tenofovir Disoproxil. It should also not be given together with adefovir disoproxil. Patients coinfected with HIV-1 and HBV: there is a risk of HIV-1 resistance developing. So in coinfected patients, Tenofovir Disoproxil should only be used as part of an appropriate antiretroviral combination regimen. Fat redistribution: in HIV-infected patients on combination antiretroviral therapy, redistribution and accumulation of body fat have been observed. This includes central obesity, dorsocervical fat enlargement (buffalo hump), peripheral wasting, facial wasting and breast enlargement. Immune Reconstitution/Redistribution Syndrome: immune reconstitution syndrome has been reported in HIV-infected patients treated with combination antiretroviral therapy, including Tenofovir Disoproxil.
Contraindications
Tenofovir Disoproxil should not be used in people who have a broken bone caused by disease or illness, an enlarged fatty liver, severe liver disease, or acute kidney disease. It should also be avoided with decreased calcification or density of the bone, a low amount of phosphate in the blood, or increased blood acidity due to high levels of lactic acid. Mothers who are producing milk and breastfeeding should not take it, and the same goes for people who are overweight.
Pregnancy & Breastfeeding
Tenofovir Disoproxil is in pregnancy category B. There are no adequate and well-controlled studies in pregnant women, so Tenofovir should be used during pregnancy only if it is clearly needed. The Centers for Disease Control and Prevention recommend that mothers infected with HIV-1 not breastfeed their infants, to avoid the risk of passing HIV-1 on after birth.
Pediatric Use
For treating HIV-1 in patients 12 years of age and older with a body weight greater than or equal to 35 kg, the dose is a 245 mg Tenofovir tablet taken orally once daily.
Geriatric Use
Clinical trials of Tenofovir did not include enough people aged 65 and over to show whether they respond differently from younger people. In general, the dose for an elderly patient should be chosen with caution, because decreased hepatic, renal or cardiac function is more frequent in this age group, and so are other diseases and other drug therapy.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Tenofovir Disoproxil at a temperature no higher than 25°C. A cool, dry place is best, away from light. Always keep it out of children's reach.
Drug Interactions
Common questions about Becovir 300 mg
What is Becovir 300 mg Tablet?
Becovir 300 mg Tablet is a medicine that contains Tenofovir Disoproxil. It is made by Beacon Pharmaceuticals PLC. It belongs to the Drugs for HIV / Anti-retroviral drugs group of medicines.
What is Becovir used for?
Tenofovir Disoproxil is used together with other antiretroviral medicines to treat HIV-1 infection. It is also used to treat chronic hepatitis B in adults.
What are the side effects of Becovir?
Tenofovir Disoproxil can cause side effects, as any medicine can. Most of them are minor and need no treatment, or they can be dealt with easily by you or your doctor.
Can I take Becovir during pregnancy or while breastfeeding?
Tenofovir Disoproxil is in pregnancy category B. There are no adequate and well-controlled studies in pregnant women, so Tenofovir should be used during pregnancy only if it is clearly needed. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Becovir?
Keep Tenofovir Disoproxil at a temperature no higher than 25°C. A cool, dry place is best, away from light.
Can I take other medicines with Becovir?
Some medicines can interact with Tenofovir Disoproxil, for example: Atazanavir, Ritonavir, Ketoprofen. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Ricovir by Radius Pharmaceuticals Ltd. has the same ingredient and strength for ৳75.00 per unit, compared with ৳85.25 for Becovir. Ask your doctor or pharmacist before switching.
Do I need a prescription for Becovir?
Becovir is a prescription (Rx) medicine. Take it as your doctor advises.