Indications
Newly diagnosed glioblastoma multiforme Zolomide is used to treat adults with newly diagnosed glioblastoma multiforme. It is given together with radiotherapy, and then continued as maintenance treatment. Refractory anaplastic astrocytoma Zolomide is also used to treat adults with refractory anaplastic astrocytoma. These are patients whose disease has progressed while they were on a drug regimen containing nitrosourea and procarbazine.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Temozolomide isn't active in its original form. At physiologic pH it converts quickly, without the help of enzymes, into a reactive compound called Methyl Triazen Imidazole Carboxamide (MTIC). MTIC is thought to kill cells mainly by alkylating DNA. The alkylation (methylation) happens mostly at the 0 6 and N 7 positions of guanine.
Pregnancy & Breastfeeding
Temozolomide is Pregnancy Category D. No adequate and well-controlled studies have been done in pregnant women. If the medicine is used during pregnancy, or if a patient becomes pregnant while taking it, she should be told about the possible hazard to the fetus. Women who could become pregnant should be advised to avoid pregnancy during treatment with Temozolomide.
It is not known whether Temozolomide passes into human milk. Many drugs do pass into milk, and there is a risk of serious adverse reactions in nursing infants. Temozolomide has also shown tumorigenicity in animal studies. For these reasons, a decision should be made either to stop nursing or to stop the medicine, taking into account how important the medicine is to the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.