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Same active ingredient — pay up to 17% less
These brands contain the same active ingredient (Temozolomide). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Zolomide
Other strengths and forms by Techno Drugs Ltd., Satipara, Narshingdi
Indications & Uses
Newly diagnosed glioblastoma multiforme Zolomide is used to treat adults with newly diagnosed glioblastoma multiforme. It is given together with radiotherapy, and then continued as maintenance treatment. Refractory anaplastic astrocytoma Zolomide is also used to treat adults with refractory anaplastic astrocytoma. These are patients whose disease has progressed while they were on a drug regimen containing nitrosourea and procarbazine.
Pharmacology
Temozolomide isn't active in its original form. At physiologic pH it converts quickly, without the help of enzymes, into a reactive compound called Methyl Triazen Imidazole Carboxamide (MTIC). MTIC is thought to kill cells mainly by alkylating DNA. The alkylation (methylation) happens mostly at the 0 6 and N 7 positions of guanine.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For newly diagnosed GBM, Temozolomide is given at 75 mg/m2 for 42 days together with focal radiotherapy. The maintenance phase follows, starting at 150 mg/m2 once daily on Days 1 to 5 of a 28-day cycle, for 6 cycles. For refractory anaplastic astrocytoma, the initial dose of Temozolomide is 150 mg/m2 once daily for 5 consecutive days in each 28-day treatment cycle.
Side Effects
Temozolomide most commonly causes alopecia, fatigue, nausea, vomiting, headache, constipation, anorexia, convulsions, rash, hemiparesis, diarrhea, asthenia, fever, dizziness, abnormal coordination, viral infection, amnesia and insomnia. The Grade 3 to 4 hematologic laboratory abnormalities seen most often during treatment with Zolomide are lymphopenia, thrombocytopenia, neutropenia and leukopenia. Allergic reactions have also been reported.
Cautions & Contraindications
Warnings & Precautions
Temozolomide can cause myelosuppression, so the Absolute Neutrophil Count (ANC) and platelet count should be checked before each dose and throughout treatment. Older patients and women are at higher risk of it. Myelodysplastic syndrome and secondary malignancies, including myeloid leukemia, have also been seen. Pneumocystis carinii pneumonia (PCP) needs prophylaxis in every patient who takes Zolomide together with radiotherapy on the 42-day regimen for newly diagnosed glioblastoma multiforme. All patients should be watched closely for lymphopenia and PCP, particularly those on steroids. Complete blood counts should be done throughout the course of treatment, as specified. Zolomide can harm the fetus when given to a pregnant woman. Women should be advised to avoid becoming pregnant while they are taking it.
Contraindications
Temozolomide must not be given to anyone who has had a hypersensitivity reaction to any of its components. It is also contraindicated in people with a past hypersensitivity to DTIC, because both medicines are metabolized to 5-(3-methyltriazen-1-yl)-imidazole-4-carboxamide MTIC).
Pregnancy & Breastfeeding
Temozolomide is Pregnancy Category D. No adequate and well-controlled studies have been done in pregnant women. If the medicine is used during pregnancy, or if a patient becomes pregnant while taking it, she should be told about the possible hazard to the fetus. Women who could become pregnant should be advised to avoid pregnancy during treatment with Temozolomide.
It is not known whether Temozolomide passes into human milk. Many drugs do pass into milk, and there is a risk of serious adverse reactions in nursing infants. Temozolomide has also shown tumorigenicity in animal studies. For these reasons, a decision should be made either to stop nursing or to stop the medicine, taking into account how important the medicine is to the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric Use: Safety and effectiveness of Temozolomide in pediatric patients have not been established.
Renal Impairment: Be careful when giving Temozolomide to patients with severe renal impairment.
Hepatic Impairment: Be careful when giving Temozolomide to patients with severe hepatic impairment.
Overdose
Doctors have studied Temozolomide clinically at doses of 500, 750, 1000 and 1250 mg/m2, counted as the total dose per cycle over 5 days. The dose-limiting toxicity was hematologic. It was reported at every dose, but it is expected to be more severe at higher doses.
One patient took an overdose of 2000 mg per day for 5 days. The reactions reported were pancytopenia, pyrexia, multi-organ failure and death.
Some patients have also taken Temozolomide for more than 5 days (up to 64 days). The reactions reported in these cases included bone marrow suppression, which in some cases was severe and prolonged, and infections. These cases resulted in death.
If an overdose happens, a hematologic evaluation is needed. Supportive measures should be given as necessary.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Temozolomide at a temperature not above 25°C, in a dry place. Protect it from light and moisture, and don't let it freeze.
Drug Interactions
Common questions about Zolomide 250 mg
What is Zolomide 250 mg Capsule?
Zolomide 250 mg Capsule is a medicine that contains Temozolomide. It is made by Techno Drugs Ltd., Satipara, Narshingdi. It belongs to the Cytotoxic Chemotherapy group of medicines.
What is Zolomide used for?
Newly diagnosed glioblastoma multiforme Zolomide is used to treat adults with newly diagnosed glioblastoma multiforme. It is given together with radiotherapy, and then continued as maintenance treatment.
What are the side effects of Zolomide?
Temozolomide most commonly causes alopecia, fatigue, nausea, vomiting, headache, constipation, anorexia, convulsions, rash, hemiparesis, diarrhea, asthenia, fever, dizziness, abnormal coordination, viral infection, amnesia and insomnia. The Grade 3 to 4 hematologic laboratory abnormalities seen most often during treatment with Zolomide are lymphopenia, thrombocytopenia, neutropenia and leukopenia.
Can I take Zolomide during pregnancy or while breastfeeding?
Temozolomide is Pregnancy Category D. No adequate and well-controlled studies have been done in pregnant women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Zolomide?
Doctors have studied Temozolomide clinically at doses of 500, 750, 1000 and 1250 mg/m2, counted as the total dose per cycle over 5 days. The dose-limiting toxicity was hematologic. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Zolomide?
Keep Temozolomide at a temperature not above 25°C, in a dry place. Protect it from light and moisture, and don't let it freeze.
Can I take other medicines with Zolomide?
Some medicines can interact with Temozolomide, for example: Sodium Valproate. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
TMZ by Jenphar Bangladesh Ltd. has the same ingredient and strength for ৳1,250.00 per unit, compared with ৳1,500.00 for Zolomide. Ask your doctor or pharmacist before switching.
Do I need a prescription for Zolomide?
Zolomide is a prescription (Rx) medicine. Take it as your doctor advises.