Indications
Tedizolid Phosphate (Tezolin) is an antibacterial from the oxazolidinone class. It is used to treat acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible isolates of certain Gram-positive microorganisms. These are Staphylococcus aureus (including methicillin-resistant and methicillin-susceptible isolates), Streptococcus pyogenes, Streptococcus agalactiae, the Streptococcus anginosus Group (including Streptococcus anginosus, Streptococcus intermedius, and Streptococcus constellatus), and Enterococcus faecalis.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Tedizolid Phosphate is a prodrug. After it is taken by mouth or given by injection into a vein, phosphatases convert it to Tedizolid, which is the microbiologically active part. With once-daily doses, steady-state concentrations of Tedizolid are reached within approximately three days, with accumulation of approximately 30% (the half-life of Tedizolid is approximately 12 hours).
When taken by mouth on an empty stomach, peak plasma Tedizolid concentrations are reached within approximately 3 hours. The absolute bioavailability is approximately 91%, so no dosage adjustment is needed when switching between the intravenous and oral routes. Tedizolid binds to human plasma proteins at approximately 70 to 90%.
Apart from Tedizolid Phosphate, which accounts for approximately 95% of the total radiocarbon AUC in plasma, there are no other significant circulating metabolites in humans. Tedizolid was not degraded in human liver microsomes, which indicates that Tedizolid Phosphate is unlikely to be a substrate for hepatic CYP450 enzymes. After a single oral dose of 14C-labeled Tedizolid Phosphate under fasted conditions, most of the elimination took place through the liver. About 82% of the radioactive dose was recovered in feces and 18% in urine.
Pregnancy & Breastfeeding
Tedizolid Phosphate is a pregnancy category C medicine. No adequate and well controlled studies have been done in pregnant women. So it should be used during pregnancy only if the possible benefit justifies the possible risk to the fetus. Whether Tedizolid Phosphate passes into human milk is not known.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.