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Community data Updated 23 hours ago

Tapentadol Hydrochloride

Opioid analgesics Prescription
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Indications

Pain

Tapentadol Hydrochloride tablet is used to relieve moderate to severe acute pain in patients aged 18 years or older.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Tapentadol is a synthetic analgesic that acts on the central nervous system. It is believed to work in two main ways, though how much each one matters clinically is not clear.

First, tapentadol is a selective mu-opioid receptor (MOR) agonist. It binds to MOR with an affinity at least ten-fold greater than its affinity for the delta- and kappa-opioid receptors.

Second, it blocks the reuptake of noradrenaline. This raises noradrenaline levels, which activates alpha-2 receptors and helps produce pain relief.

Tapentadol is also a weak serotonin reuptake inhibitor, but this action does not add to its analgesic effect.

Pregnancy & Breastfeeding

Tapentadol is a Pregnancy Category C medicine. No adequate and well-controlled studies have been done in pregnant women, so doctors should prescribe it during pregnancy only when the possible benefit to the mother justifies the possible risk to the fetus. Babies born to mothers who have been taking Tapentadol should be monitored for respiratory depression.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Tapentadol Hydrochloride is a centrally acting painkiller, and like others of its kind the dose has to be set for the individual patient. The doctor decides it by looking at how severe the pain is, what experience the patient has had with similar medicines, and whether the patient can be monitored properly. The usual dose is 50 mg, 75 mg or 100 mg every 4 to 6 hours, depending on how strong the pain is. On the first day, if the first dose doesn't give enough relief, the second dose can be given as early as one hour after it. After that, the dose stays at 50 mg, 75 mg or 100 mg every 4 to 6 hours, and it should be adjusted so that pain stays well controlled and the patient tolerates the medicine acceptably. Daily doses above 700 mg on the first day of treatment, and above 600 mg on the days after, have not been studied and are not recommended.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.