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Indications & Uses
Tapexia is indicated for:
Pharmacology
Tapentadol is a synthetic analgesic that acts on the central nervous system. It is believed to work in two main ways, though how much each one matters clinically is not clear.
First, tapentadol is a selective mu-opioid receptor (MOR) agonist. It binds to MOR with an affinity at least ten-fold greater than its affinity for the delta- and kappa-opioid receptors.
Second, it blocks the reuptake of noradrenaline. This raises noradrenaline levels, which activates alpha-2 receptors and helps produce pain relief.
Tapentadol is also a weak serotonin reuptake inhibitor, but this action does not add to its analgesic effect.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Tapentadol Hydrochloride is a centrally acting painkiller, and like others of its kind the dose has to be set for the individual patient. The doctor decides it by looking at how severe the pain is, what experience the patient has had with similar medicines, and whether the patient can be monitored properly.
The usual dose is 50 mg, 75 mg or 100 mg every 4 to 6 hours, depending on how strong the pain is. On the first day, if the first dose doesn't give enough relief, the second dose can be given as early as one hour after it. After that, the dose stays at 50 mg, 75 mg or 100 mg every 4 to 6 hours, and it should be adjusted so that pain stays well controlled and the patient tolerates the medicine acceptably.
Daily doses above 700 mg on the first day of treatment, and above 600 mg on the days after, have not been studied and are not recommended.
Side Effects
Tapentadol Hydrochloride can cause a number of side effects that appear during treatment. These include a faster or slower heart rate, visual disturbance, abdominal discomfort, impaired gastric emptying, irritability, edema, drug withdrawal syndrome, hypersensitivity and involuntary muscle contractions. Some people feel a sensation of heaviness, hypoesthesia or paresthesia. Others may have a disturbance in attention, sedation, dysarthria, memory impairment, ataxia, presyncope or syncope. Abnormal coordination, seizure, urticaria and decreased blood pressure may also happen, among others.
Cautions & Contraindications
Warnings & Precautions
Tapentadol Hydrochloride should be given with caution to patients who have conditions with hypoxia or hypercapnia, and to those with respiratory problems such as asthma and chronic obstructive pulmonary disease. Patients with sleep apnea syndrome, myxedema, kyphoscoliosis or central nervous system (CNS) depression also need care before Tapentadol Hydrochloride is started. Patients who take other mu-opioid agonist analgesics, general anesthetics, phenothiazines, other tranquilizers, sedatives, hypnotics or other CNS depressants (including alcohol) together with Tapentadol Hydrochloride may show additive CNS depression.
Contraindications
Tapentadol Hydrochloride should not be given to patients with impaired pulmonary function. It is also contraindicated in acute or severe bronchial asthma, and in hypercapnia, when the patient is in an unmonitored setting or when no resuscitative equipment is available. Don't use it in any patient who has, or is suspected of having, paralytic ileus.
Pregnancy & Breastfeeding
Tapentadol is a Pregnancy Category C medicine. No adequate and well-controlled studies have been done in pregnant women, so doctors should prescribe it during pregnancy only when the possible benefit to the mother justifies the possible risk to the fetus. Babies born to mothers who have been taking Tapentadol should be monitored for respiratory depression.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: Tapentadol Hydrochloride hasn't been shown to be safe or effective in patients under 18 years of age.
Use in elderly patients: In general, the recommended dose for elderly patients with normal kidney and liver function is the same as for younger adults with normal kidney and liver function. Still, doctors should consider starting elderly patients at the lower end of the recommended dose range.
Use in renal disease: In patients with severe renal impairment, the safety and effectiveness of Tapentadol Hydrochloride have not been established.
Use in hepatic disease: Tapentadol Hydrochloride should be used with caution in patients with moderate hepatic impairment. It has not been studied in patients with severe hepatic impairment.
Storage
Keep Tapentadol Hydrochloride in a cool, dry place, away from light and moisture. Always store the medicine where children can't reach it.
Drug Interactions
Common questions about Tapexia 50 mg
What is Tapexia 50 mg Tablet?
Tapexia 50 mg Tablet is a medicine that contains Tapentadol Hydrochloride. It is made by Globe Pharmaceuticals Ltd. It belongs to the Opioid analgesics group of medicines.
What is Tapexia used for?
Tapexia is used for: Pain.
What are the side effects of Tapexia?
Tapentadol Hydrochloride can cause a number of side effects that appear during treatment. These include a faster or slower heart rate, visual disturbance, abdominal discomfort, impaired gastric emptying, irritability, edema, drug withdrawal syndrome, hypersensitivity and involuntary muscle contractions.
Can I take Tapexia during pregnancy or while breastfeeding?
Tapentadol is a Pregnancy Category C medicine. No adequate and well-controlled studies have been done in pregnant women, so doctors should prescribe it during pregnancy only when the possible benefit to the mother justifies the possible risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Tapexia?
Keep Tapentadol Hydrochloride in a cool, dry place, away from light and moisture. Always store the medicine where children can't reach it.
Can I take other medicines with Tapexia?
Some medicines can interact with Tapentadol Hydrochloride, for example: Rifampicin, Buprenorphine, Pentazocine, Phenobarbital, Nalbuphine Hydrochloride, Noradrenaline. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Tapexia is already among the lowest-priced brands of Tapentadol Hydrochloride at this strength.
Do I need a prescription for Tapexia?
Tapexia is a prescription (Rx) medicine. Take it as your doctor advises.