Indications
Rosuvastatin + Ezetimibe combines rosuvastatin, an HMG CoA-reductase inhibitor (statin), with ezetimibe, which blocks the absorption of dietary cholesterol. The combination is indicated in adults. It is used as an adjunct to diet in patients with primary non-familial hyperlipidemia, to reduce low-density lipoprotein cholesterol (LDL-C). It is also used, alone or as an adjunct to other LDL-C lowering therapies, in patients with homozygous familial hypercholesterolemia (HoFH), again to reduce LDL-C.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Rosuvastatin lowers plasma cholesterol and lipoprotein levels in two ways. It inhibits HMG-CoA reductase, which slows cholesterol synthesis in the liver, and it increases the number of LDL receptors on the surface of liver cells, so more LDL is taken up and broken down. The result is that rosuvastatin reduces LDL production and the number of LDL particles.
Ezetimibe lowers blood cholesterol by blocking the absorption of cholesterol in the small intestine. Its molecular target has been shown to be the sterol transporter, which is involved in the intestinal uptake of cholesterol and phytosterols.
Pregnancy & Breastfeeding
Rosuvastatin + Ezetimibe must not be used by women who are pregnant or who may become pregnant. It is also not recommended during breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.