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Same active ingredient — pay up to 8% less
These brands contain the same active ingredient (Rosuvastatin + Ezetimibe). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Rosu EZ
Other strengths and forms by Popular Pharmaceuticals PLC
Indications & Uses
Rosu EZ is indicated for:
Pharmacology
Rosuvastatin lowers plasma cholesterol and lipoprotein levels in two ways. It inhibits HMG-CoA reductase, which slows cholesterol synthesis in the liver, and it increases the number of LDL receptors on the surface of liver cells, so more LDL is taken up and broken down. The result is that rosuvastatin reduces LDL production and the number of LDL particles.
Ezetimibe lowers blood cholesterol by blocking the absorption of cholesterol in the small intestine. Its molecular target has been shown to be the sterol transporter, which is involved in the intestinal uptake of cholesterol and phytosterols.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual dose of Rosuvastatin + Ezetimibe is between 5/10 mg and 40/10 mg, taken by mouth once a day. The dose your doctor chooses depends on why you need the medicine, your LDL-C level, and your own risk of cardiovascular events.
For patients with severe renal impairment (not on hemodialysis), the starting dose is 5 mg/10 mg once daily. The dose should not go above 10 mg/10 mg once daily.
Swallow the tablet whole. Don't crush it, dissolve it or chew it.
If you also take a bile acid sequestrant, take this medicine at least 2 hours before it or 4 hours after it. If you take an aluminium and magnesium hydroxide combination antacid, take this medicine at least 2 hours before the antacid.
Pediatric Use
Safety and effectiveness have not been established in pediatric patients.
Geriatric Use
No dosage adjustment is necessary.
Side Effects
Rosuvastatin + Ezetimibe can cause headache, nausea, muscle pain (myalgia) and joint pain (arthralgia). Dizziness, weakness (asthenia), constipation and abdominal pain are also common. Some people get a respiratory tract infection, diarrhea, sinusitis or pain in the arms and legs. Fatigue, influenza and back pain complete the list.
Cautions & Contraindications
Warnings & Precautions
Myopathy and rhabdomyolysis The risk is higher in people aged 65 years or more, and in those with uncontrolled hypothyroidism, kidney impairment, or higher doses. Using certain other medicines at the same time also raises the risk. Stop Rosuvastatin + Ezetimibe if creatine kinase (CK) levels are markedly raised, or if myopathy is diagnosed or suspected. It should also be stopped for a time in a patient who has an acute or serious condition that puts them at high risk of kidney failure secondary to rhabdomyolysis. Hepatic dysfunction Serum transaminases have risen in some patients, and in some of them the rise has persisted. There are rare reports of hepatic failure, both fatal and non-fatal. Consider doing liver enzyme tests before starting treatment, and again later as clinically indicated.
Contraindications
Do not give Rosuvastatin + Ezetimibe to patients with active liver disease or decompensated cirrhosis, or to anyone with hypersensitivity to any component.
Pregnancy & Breastfeeding
Rosuvastatin + Ezetimibe must not be used by women who are pregnant or who may become pregnant. It is also not recommended during breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Patients with Hepatic Impairment: Rosuvastatin + Ezetimibe must not be used in patients with acute liver failure or decompensated cirrhosis. If serious liver injury occurs with clinical symptoms and/or hyperbilirubinemia or jaundice, stop the medicine promptly.
Patients with Renal Impairment: In patients with severe renal impairment (CrCl less than 30 mL/min/1.73 m2) who are not on hemodialysis, the recommended starting dosage is 5 mg/10 mg once daily, and it should not go above 10 mg/10 mg once daily. For mild and moderate renal impairment, there are no dosage adjustment recommendations.
Storage
Keep Rosuvastatin + Ezetimibe below 30°C, and away from light and moisture. As with all medicines, keep it out of the reach of children.
Drug Interactions
Common questions about Rosu EZ 5 mg+10 mg
What is Rosu EZ 5 mg+10 mg Tablet?
Rosu EZ 5 mg+10 mg Tablet is a medicine that contains Rosuvastatin + Ezetimibe. It is made by Popular Pharmaceuticals PLC. It belongs to the Other lipid regulating drugs group of medicines.
What is Rosu EZ used for?
Rosu EZ is used for: Hyperlipidemia.
What are the side effects of Rosu EZ?
Rosuvastatin + Ezetimibe can cause headache, nausea, muscle pain (myalgia) and joint pain (arthralgia). Dizziness, weakness (asthenia), constipation and abdominal pain are also common.
Can I take Rosu EZ during pregnancy or while breastfeeding?
Rosuvastatin + Ezetimibe must not be used by women who are pregnant or who may become pregnant. It is also not recommended during breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Rosu EZ?
Keep Rosuvastatin + Ezetimibe below 30°C, and away from light and moisture. As with all medicines, keep it out of the reach of children.
Can I take other medicines with Rosu EZ?
Some medicines can interact with Rosuvastatin + Ezetimibe, for example: Cyclosporine, Rosuvastatin, Ezetimibe, Niacin, Colchicine, Regorafenib. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Creston EZ by Eskayef Pharmaceuticals Ltd. has the same ingredient and strength for ৳12.00 per unit, compared with ৳13.00 for Rosu EZ. Ask your doctor or pharmacist before switching.
Do I need a prescription for Rosu EZ?
Rosu EZ is a prescription (Rx) medicine. Take it as your doctor advises.