Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago
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Indications

Myocardial Infarction Hyperlipidemia Stroke

RVN tablet (rosuvastatin calcium) is used in several groups of patients. In primary hyperlipidemia and mixed dyslipidemia, it is given as an adjunct to diet to reduce elevated total-C, LDL-C, ApoB, non HDL-C and TG levels and to increase HDL-C. It is also an adjunct to diet in patients with hypertriglyceridemia, and in patients with primary dysbetalipoproteinemia (Type III hyperlipoproteinemia). In patients with homozygous familial hypercholesterolemia (HoFH), RVN tablet is used to reduce LDL-C, total-C and ApoB. It is also used to slow the progression of atherosclerosis, as part of a treatment strategy to lower total-C and LDL-C, again as an adjunct to diet. Pediatric patients 10 to 17 years of age with heterozygous familial hypercholesterolemia (HeFH) can take it to reduce elevated total-C, LDL-C and ApoB, once an adequate trial of diet therapy has failed. The last use is risk reduction of Myocardial Infarction (MI), stroke and arterial revascularization procedures in patients who have no clinically evident CHD but have multiple risk factors.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase. This enzyme sets the pace for the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, which is a precursor of cholesterol. Rosuvastatin changes blood lipids in two ways. First, it raises the number of LDL receptors on the surface of liver cells, so the liver takes up and breaks down more LDL. Second, it blocks the liver's synthesis of VLDL, and this lowers the total number of VLDL and LDL particles.

Pregnancy & Breastfeeding

Rosuvastatin should be given to women who could become pregnant only when they are highly unlikely to conceive and have been told about the possible hazards. If a woman becomes pregnant while she is taking rosuvastatin, the treatment should be stopped immediately. It isn't known whether rosuvastatin passes into human milk, but a small amount of another medicine in this class does pass into breast milk.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Heterozygous Familial Hypercholesterolemia in Pediatric Patients (10 to 17 years of age): The usual dose range of Rosuvastatin is 5 to 20 mg a day, and the maximum recommended dose is 20 mg a day (doses above 20 mg have not been studied in this patient group). Doses should be individualized according to the recommended goal of therapy. Adjustments should be made at intervals of 4 weeks or more. Very High Cholesterol and High Risk of MI or Stroke: 40 mg once daily. Homozygous Familial Hypercholesterolemia: The recommended starting dose of Rosuvastatin is 20 mg once daily. Response to therapy should be estimated from preapheresis LDL-C levels. Dosage in Asian Patients: Starting Rosuvastatin at 5 mg once daily should be considered for Asian patients. Use with Cyclosporine, Lopinavir/Ritonavir or Atazanavir/Ritonavir: In patients taking Cyclosporine, the dose of Rosuvastatin should be limited to 5 mg once daily. In patients taking Lopinavir and Ritonavir together, or Atazanavir and Ritonavir together, the dose of Rosuvastatin should be limited to 10 mg once daily. Concomitant Lipid-Lowering Therapy: The risk of skeletal muscle effects may be higher when Rosuvastatin is used with Niacin or Fenofibrate, so a lower Rosuvastatin dose should be considered in this setting. Combination with Gemfibrozil should be avoided because it raises Rosuvastatin exposure. If Rosuvastatin is used with Gemfibrozil, the dose of Rosuvastatin should be limited to 10 mg once daily. Dosage in Patients with Severe Renal Impairment: For patients with severe renal impairment (ClCr<30 mL/min/1.73 m²) who are not on hemodialysis, Rosuvastatin should be started at 5 mg once daily and should not go above 10 mg once daily.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.