Indications
Rifampicin and Isoniazid belongs to a group of medicines called antituberculosis agents. It's a fixed combination of two very effective antituberculosis medicines, and together they stop the growth of mycobacteria, the germs that cause tuberculosis. Rifampicin and Isoniazid is used for the continuation phase treatment of tuberculosis.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Rifampicin and isoniazid are both bactericidal anti-TB drugs. They work especially well against rapidly growing extracellular organisms, and they also kill bacteria inside cells. Rifampicin blocks the activity of DNA-dependent RNA polymerase in susceptible cells. It acts on the bacterial RNA polymerase and does not inhibit the mammalian enzyme. Cross-resistance to rifampicin has only been shown with other rifamycins. Rifampicin is also active against slow-growing and intermittently growing M. tuberculosis. Isoniazid acts against actively growing tubercle bacilli.
Pregnancy & Breastfeeding
Rifampicin + Isoniazid is a Pregnancy Category C medicine. Animal reproduction studies have shown an adverse effect on the fetus, and there are no adequate and well-controlled studies in humans. Even so, the possible benefits may justify using the medicine in a pregnant woman despite the possible risks.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.