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Indications & Uses
Rimactazid is indicated for:
Pharmacology
Rifampicin and isoniazid are both bactericidal anti-TB drugs. They work especially well against rapidly growing extracellular organisms, and they also kill bacteria inside cells. Rifampicin blocks the activity of DNA-dependent RNA polymerase in susceptible cells. It acts on the bacterial RNA polymerase and does not inhibit the mammalian enzyme. Cross-resistance to rifampicin has only been shown with other rifamycins. Rifampicin is also active against slow-growing and intermittently growing M. tuberculosis. Isoniazid acts against actively growing tubercle bacilli.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For adults under 50 kg body weight, the dose of Rifampicin + Isoniazid is 3 tablets of 150/100 once daily, or 1 tablet of 450/300 once daily. For adults over 50 kg, it is 2 tablets of 300/150 once daily.
In hepatic impairment, the maximum is 8 mg/kg daily.
Side Effects
Unwanted effects may occur during continuous daily or intermittent therapy. Rifampicin may turn body fluids, and occasionally other secretions, reddish. This can affect urine, sputum, lacrimal fluid, faeces, saliva and sweat. It may also permanently discolour soft contact lenses. Hepatic effects: an increase in liver enzymes without any symptoms is very common (>10%). Severe, life-threatening liver reactions such as hepatic failure and acute fulminant hepatitis are uncommon (>0.1% and <1%). In isolated cases (<0.01 %), the outcome was fatal. Renal effects: BUN and serum uric acid may rise. Haemolysis, haematuria, interstitial nephritis and renal insufficiency can also occur. Gastrointestinal effects: nausea, abdominal pains, vomiting or diarrhoea, and pseudomembranous colitis. Central and peripheral nervous system effects: tiredness, drowsiness, headache, dizziness, ataxia, mental confusion, muscular weakness and visual disturbances. Haematological changes: leucopenia, eosinophilia, thrombocytopenia and thrombocytopenic purpura. Effects on skin and appendages: flushing, itching with or without skin rash, urticaria, reddening of the eyes and exudative conjunctivitis. Generalised hypersensitivity reactions involving the skin can also happen, for example exfoliative dermatitis, Lyell's syndrome and pemphigoid reactions. Endocrine effects: disturbances in the menstrual cycle, and induction of crisis in Addison patients. Unwanted effects chiefly occurring during intermittent therapy or upon resumption of treatment after temporary interruption
Cautions & Contraindications
Warnings & Precautions
Isoniazid needs careful monitoring in the following people. First are those who drink alcohol every day, since daily drinking may be linked to a higher rate of isoniazid hepatitis. Next are patients with active chronic liver disease or severe renal dysfunction, and anyone over 35. Watch closely too if the patient takes any other medicine regularly over a long period, or has had isoniazid stopped in the past. The same care applies to people with peripheral neuropathy or a condition that makes neuropathy more likely, and to women who are pregnant. Injection drug users also need close monitoring. So do women from minority groups, particularly in the post-partum period, and HIV seropositive patients.
Contraindications
Don't use this medicine if you are known or thought to be allergic to rifamycins or to INH, or to any of the excipients, including if you have had drug-induced hepatitis. It must also not be used in acute liver disease, whatever the cause, or in peripheral neuritis.
Pregnancy & Breastfeeding
Rifampicin + Isoniazid is a Pregnancy Category C medicine. Animal reproduction studies have shown an adverse effect on the fetus, and there are no adequate and well-controlled studies in humans. Even so, the possible benefits may justify using the medicine in a pregnant woman despite the possible risks.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Rifampicin + Isoniazid below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Rimactazid 300 mg+150 mg
What is Rimactazid 300 mg+150 mg Tablet?
Rimactazid 300 mg+150 mg Tablet is a medicine that contains Rifampicin + Isoniazid. It is made by Nevian Lifescience PLC. It belongs to the Anti-tubercular antibiotics group of medicines.
What is Rimactazid used for?
Rimactazid is used for: Tuberculosis.
What are the side effects of Rimactazid?
Unwanted effects may occur during continuous daily or intermittent therapy. Rifampicin may turn body fluids, and occasionally other secretions, reddish.
Can I take Rimactazid during pregnancy or while breastfeeding?
Rifampicin + Isoniazid is a Pregnancy Category C medicine. Animal reproduction studies have shown an adverse effect on the fetus, and there are no adequate and well-controlled studies in humans. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Rimactazid?
Store Rifampicin + Isoniazid below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Rimactazid?
Some medicines can interact with Rifampicin + Isoniazid, for example: Haloperidol, Carbamazepine, Ciprofloxacin, Halothane, Isoniazid, Chloramphenicol. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Rimactazid is already among the lowest-priced brands of Rifampicin + Isoniazid at this strength.
Do I need a prescription for Rimactazid?
Rimactazid is a prescription (Rx) medicine. Take it as your doctor advises.