Indications
Revefenacin nebulizer solution is used for the maintenance treatment of people with chronic obstructive pulmonary disease (COPD).
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Revefenacin is a long-acting muscarinic antagonist, a type of medicine often called an anticholinergic. It binds with similar affinity to all the muscarinic receptor subtypes, M1 to M5. In the airways, it works by blocking the M3 receptor on the smooth muscle, and this leads to bronchodilation.
Studies on receptors of human and animal origin and on isolated organ preparations showed that the blocking effect is competitive and reversible. In preclinical in vitro and in vivo models, revefenacin prevented the bronchoconstriction caused by methacholine and acetylcholine. This protection depended on the dose and lasted longer than 24 hours. The clinical relevance of these findings is unknown. After inhalation, the bronchodilation from revefenacin is mainly a site-specific effect.
Pregnancy & Breastfeeding
There are no adequate and well-controlled studies of Revefenacin in pregnant women. Women should be told to contact their physician if they become pregnant while taking Revefenacin. In animal reproduction studies, revefenacin was given by subcutaneous administration to pregnant rats and rabbits during the period of organogenesis. It produced no evidence of fetal harm at exposures approximately 209 times the exposure at the maximum recommended human dose (MRHD).
There is no information on whether revefenacin is present in human milk, what effects it has on the breastfed infant, or what effects it has on milk production. Revefenacin was, however, present in the milk of lactating rats after dosing during pregnancy and lactation. The developmental and health benefits of breastfeeding should be considered together with the mother's clinical need for Revefenacin, and with any potential adverse effects on the breastfed infant from Revefenacin or from the underlying maternal condition.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.