Rebreath Respiratory
Rx175 mcg • Nebuliser Solution
Indications & Uses
Rebreath Respiratory is indicated for:
Pharmacology
Revefenacin is a long-acting muscarinic antagonist, a type of medicine often called an anticholinergic. It binds with similar affinity to all the muscarinic receptor subtypes, M1 to M5. In the airways, it works by blocking the M3 receptor on the smooth muscle, and this leads to bronchodilation.
Studies on receptors of human and animal origin and on isolated organ preparations showed that the blocking effect is competitive and reversible. In preclinical in vitro and in vivo models, revefenacin prevented the bronchoconstriction caused by methacholine and acetylcholine. This protection depended on the dose and lasted longer than 24 hours. The clinical relevance of these findings is unknown. After inhalation, the bronchodilation from revefenacin is mainly a site-specific effect.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dose of Revefenacin is 175 mcg (one 175 mcg unit-dose vial), taken by oral inhalation once daily. It is given by nebulizer with a mouthpiece, using a standard jet nebulizer connected to an air compressor. Nebulizer systems that don't use a compressor haven't been tested for safety and efficacy with Revefenacin, so that has not been established.
Take the Revefenacin vial out of its foil pouch and open it only immediately before use. After the dose, throw away the vial and anything left in it.
Use in children and adolescents: efficacy and safety in those under 18 years have not been established.
Geriatric use: going by the available data, older patients don't need any change in the Revefenacin dose.
Renal impairment: patients with renal impairment don't need a dose adjustment.
Side Effects
Revefenacin can cause a few common side effects: cough, runny nose, upper respiratory tract infection and headache. Some side effects are serious. These are glaucoma, eye pain, blurred vision and painful urination. Rash and swelling of the face, mouth and tongue are also serious.
Cautions & Contraindications
Warnings & Precautions
Deterioration of disease and acute episodes Revefenacin should not be started in patients whose COPD is getting worse quickly or who are having a potentially life-threatening episode. It has not been studied in people with acutely deteriorating COPD, so starting it in that situation is not appropriate. Revefenacin is a once-daily maintenance treatment for COPD. Don't use it for relief of acute symptoms, that is, as rescue therapy for an acute episode of bronchospasm, and don't give extra doses for that purpose. Acute symptoms should be treated with an inhaled, short-acting beta2-agonist. COPD can get worse over a period of hours, or slowly over several days or longer. These may be signs that the disease is deteriorating: Revefenacin no longer controls the symptoms of bronchoconstriction, the patient's inhaled short-acting beta2-agonist becomes less effective, or the patient needs more inhalations of a short-acting beta2-agonist than usual. In this situation the patient and the COPD treatment regimen should be re-evaluated at once. Raising the daily dose of Revefenacin above the recommended dose is not appropriate here. Paradoxical bronchospasm Like other inhaled medicines, Revefenacin can cause paradoxical bronchospasm, and it may be life-threatening. If it happens after a dose of Revefenacin, treat it immediately with an inhaled, short-acting bronchodilator. Stop Revefenacin immediately and start alternative therapy. Worsening of narrow-angle glaucoma Use Revefenacin with caution in patients with narrow-angle glaucoma. Prescribers and patients should watch for signs and symptoms of acute narrow-angle glaucoma (for example eye pain or discomfort, blurred vision, visual halos or colored images together with red eyes from conjunctival congestion and corneal edema). Patients should be told to consult a physician immediately if any of these develops. Worsening of urinary retention Use Revefenacin with caution in patients with urinary retention. Prescribers and patients should watch for signs and symptoms of urinary retention (for example difficulty passing urine, painful urination), especially in patients with prostatic hyperplasia or bladder-neck obstruction. Patients should be told to consult a doctor immediately if any of these develops. Immediate hypersensitivity reactions Immediate hypersensitivity reactions may occur after Revefenacin is given. If one happens, stop Revefenacin at once and consider alternative treatments.
Contraindications
Don't give Revefenacin to anyone who is allergic to it, or to any other ingredient in the product.
Pregnancy & Breastfeeding
There are no adequate and well-controlled studies of Revefenacin in pregnant women. Women should be told to contact their physician if they become pregnant while taking Revefenacin. In animal reproduction studies, revefenacin was given by subcutaneous administration to pregnant rats and rabbits during the period of organogenesis. It produced no evidence of fetal harm at exposures approximately 209 times the exposure at the maximum recommended human dose (MRHD).
There is no information on whether revefenacin is present in human milk, what effects it has on the breastfed infant, or what effects it has on milk production. Revefenacin was, however, present in the milk of lactating rats after dosing during pregnancy and lactation. The developmental and health benefits of breastfeeding should be considered together with the mother's clinical need for Revefenacin, and with any potential adverse effects on the breastfed infant from Revefenacin or from the underlying maternal condition.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Taking too much Revefenacin can cause anticholinergic signs and symptoms. These include nausea, vomiting, dizziness, lightheadedness, blurred vision, fatigue, or difficulty in passing urine. It can also raise the pressure inside the eye (intraocular pressure), which may cause eye pain, vision disturbances or reddening of the eye.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Revefenacin below 30°C in a dry place, and protect it from direct sunlight and heat. Like all medicines, it must be kept out of reach of children. Once you've used the ampoule, throw it away along with any other parts. It is not for oral use and must not be injected.
Drug Interactions
Common questions about Rebreath Respiratory 175 mcg
What is Rebreath Respiratory 175 mcg Nebuliser Solution?
Rebreath Respiratory 175 mcg Nebuliser Solution is a medicine that contains Revefenacin. It is made by The ACME Laboratories Ltd. It belongs to the Anticholinergic bronchodilators group of medicines.
What is Rebreath Respiratory used for?
Rebreath Respiratory is used for: Chronic Obstructive Pulmonary Disease.
What are the side effects of Rebreath Respiratory?
Revefenacin can cause a few common side effects: cough, runny nose, upper respiratory tract infection and headache. Some side effects are serious.
Can I take Rebreath Respiratory during pregnancy or while breastfeeding?
There are no adequate and well-controlled studies of Revefenacin in pregnant women. Women should be told to contact their physician if they become pregnant while taking Revefenacin. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Rebreath Respiratory?
Taking too much Revefenacin can cause anticholinergic signs and symptoms. These include nausea, vomiting, dizziness, lightheadedness, blurred vision, fatigue, or difficulty in passing urine. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Rebreath Respiratory?
Keep Revefenacin below 30°C in a dry place, and protect it from direct sunlight and heat. Like all medicines, it must be kept out of reach of children.
Can I take other medicines with Rebreath Respiratory?
Some medicines can interact with Revefenacin, for example: Cyclosporine, Rifampicin. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Rebreath Respiratory?
Rebreath Respiratory is a prescription (Rx) medicine. Take it as your doctor advises.