Indications
Pamulin ointment is used on the skin to treat impetigo in adults and in children aged 9 months and older. It works on impetigo caused by Staphylococcus aureus (only the methicillin-susceptible strains) or Streptococcus pyogenes. For adults, it can be used on an area of up to 100 cm² in total, and for children aged 9 months or older, up to 2% of the total body surface area. Its safety in babies younger than 9 months has not been established. Pamulin should only be used for infections that are proven, or strongly suspected, to be caused by bacteria it can kill. This helps slow the spread of drug-resistant bacteria and keeps Pamulin and other antibacterial medicines working well for people who need them.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Retapamulin works by selectively blocking bacterial protein synthesis, attaching to a distinct site on the 50S subunit of the bacterial ribosome through a mechanism unlike that of other antibiotics. This binding site involves ribosomal protein L3 and lies within the region of the ribosomal P-site and peptidyl transferase center. By attaching here, pleuromutilins such as retapamulin block peptidyl transfer, interfere with P-site interactions, and stop the normal assembly of functional 50S ribosomal subunits. Against Staphylococcus aureus and Streptococcus pyogenes, retapamulin acts as a bacteriostatic agent at its in vitro minimum inhibitory concentration (MIC) for these organisms.
Pregnancy & Breastfeeding
Pregnancy Category B. It is not known whether retapamulin passes into breast milk. Since many medicines do pass into breast milk, it should be used with caution in women who are breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.