Pricing
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Topibac is indicated for:
Pharmacology
Retapamulin works by selectively blocking bacterial protein synthesis, attaching to a distinct site on the 50S subunit of the bacterial ribosome through a mechanism unlike that of other antibiotics. This binding site involves ribosomal protein L3 and lies within the region of the ribosomal P-site and peptidyl transferase center. By attaching here, pleuromutilins such as retapamulin block peptidyl transfer, interfere with P-site interactions, and stop the normal assembly of functional 50S ribosomal subunits. Against Staphylococcus aureus and Streptococcus pyogenes, retapamulin acts as a bacteriostatic agent at its in vitro minimum inhibitory concentration (MIC) for these organisms.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
A thin layer of Topibac should be applied to the affected area (up to 100 cm2 in total area in adults, or 2% total body surface area in pediatric patients aged 9 months or older) twice daily for 5 days. The treated area may be covered with a sterile bandage or gauze dressing if desired.
Side Effects
Application site irritation may occur, affecting fewer than 2% of patients.
Cautions & Contraindications
Warnings & Precautions
Local Irritation: If Pamulin causes sensitization or severe local irritation, stop using it. Not for Systemic or Mucosal Use: Pamulin should not be swallowed, and it is not meant to be used in the mouth, nose, eyes, or vagina.
Contraindications
Contraindicated in patients who are hypersensitive to any ingredient in this preparation.
Pregnancy & Breastfeeding
Pregnancy Category B. It is not known whether retapamulin passes into breast milk. Since many medicines do pass into breast milk, it should be used with caution in women who are breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Retapamulin below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Common questions about Topibac 1%
What is Topibac 1% Ointment?
Topibac 1% Ointment is a medicine that contains Retapamulin. It is made by Popular Pharmaceuticals PLC. It belongs to the Topical Antibiotic preparations group of medicines.
What is Topibac used for?
Topibac is used for: Bacterial Infection.
What are the side effects of Topibac?
Application site irritation may occur, affecting fewer than 2% of patients.
Can I take Topibac during pregnancy or while breastfeeding?
Pregnancy Category B. It is not known whether retapamulin passes into breast milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Topibac?
Store Retapamulin below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Do I need a prescription for Topibac?
Topibac is a prescription (Rx) medicine. Take it as your doctor advises.