Indications
Pyridoxine Hydrochloride + Doxylamine Succinate is used to treat nausea and vomiting of pregnancy. It is meant for women who have not responded to conservative management.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Doxylamine Succinate is an antihistamine that blocks the histamine (H1) receptor. It can cross the blood brain barrier and has a high affinity for H1 receptors in the brain, so it blocks them there. It also lowers the action of histamine at the H1 receptor by inhibiting both the vestibular system and the muscarinic receptor. Its effect on the vestibular system reduces the stimulation of the vomiting center. The muscarinic receptor inhibition may also play a part in its antihistamine antiemetic activity.
Pyridoxine Hydrochloride is a vitamin B6 analog. It is used to prevent nausea and vomiting because of its antiemetic properties.
Pregnancy & Breastfeeding
Pyridoxine Hydrochloride with Doxylamine Succinate is placed in pregnancy category A. It is meant for nausea and vomiting of pregnancy in women who haven't responded to conservative management. Both Doxylamine Succinate and Pyridoxine Hydrochloride pass into breast milk, so a breastfeeding mother should take care when using this medicine.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.