Pseudoephedrine + Guaiphenasine + Triprolidine

Guaiphenesin works as an expectorant. It makes sputum less thick by increasing the volume and water content of the bronchial secretion, so the sputum is easier to bring up. Pseudoephedrine has both direct and indirect sympathomimetic activity and is an effective decongestant for the upper respiratory tract. Compared with ephedrine, it is substantially less potent in causing tachycardia and a rise in systolic blood pressure, and considerably less potent in stimulating the central nervous system. Triporlidine gives symptomatic relief in conditions believed to depend wholly or partly on the triggered release of histamine. It is a potent competitive histamine H1-receptor antagonist of the pyrrolidine class. It also has mild central nervous system depressant properties, which may cause drowsiness.

This syrup is absorbed from the gastrointestinal tract. Guaiphenesin is metabolized and passes out in the urine. Pseudoephedrine is mostly excreted unchanged in the urine, along with small amounts of its hepatic metabolite. Triprolidine is metabolized in the liver and usually leaves the body in the urine as metabolites.