Indications
Prucalo tablet is used for the symptomatic treatment of chronic constipation in adults. It is meant for people whose constipation has not been relieved well enough by laxatives.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Prucalopride is a selective stimulator of the 5-HT4 receptors. It doesn't interact with the hERG channel or the 5-HT1 receptors, and this greatly reduces the cardiovascular risk seen with other similar drugs. 5-HT4 receptors are found throughout the gastrointestinal tract, mainly in smooth muscle cells, enterochromaffin cells and the myenteric plexus. When they are activated, acetylcholine is released, and acetylcholine is the major excitatory neurotransmitter in the GI tract.
So prucalopride stimulates motility by acting specifically on the 5-HT4 receptors in the GI tract. This causes acetylcholine to be released, which leads to further contraction of the muscle layer of the colon and relaxation of the circular muscle layer. The result is propulsion of the luminal content.
Pregnancy & Breastfeeding
Prucalopride is not recommended during pregnancy, and women who could become pregnant should use effective contraception while they are on treatment. Animal studies have not shown any direct or indirect harmful effects on pregnancy, embryonal or fetal development, parturition or postnatal development. There are no human data on breastfeeding, so Prucalopride is not recommended for use while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.