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Indications & Uses
Resolax is indicated for:
Pharmacology
Prucalopride is a selective stimulator of the 5-HT4 receptors. It doesn't interact with the hERG channel or the 5-HT1 receptors, and this greatly reduces the cardiovascular risk seen with other similar drugs. 5-HT4 receptors are found throughout the gastrointestinal tract, mainly in smooth muscle cells, enterochromaffin cells and the myenteric plexus. When they are activated, acetylcholine is released, and acetylcholine is the major excitatory neurotransmitter in the GI tract.
So prucalopride stimulates motility by acting specifically on the 5-HT4 receptors in the GI tract. This causes acetylcholine to be released, which leads to further contraction of the muscle layer of the colon and relaxation of the circular muscle layer. The result is propulsion of the luminal content.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults take Prucalopride Succinate 2 mg once daily, with or without food, at any time of the day. Prucalopride works by stimulating propulsive motility, so going above 2 mg a day is not expected to make it work any better.
Older people should start with 1 mg once daily. If needed, the dose can be raised to 2 mg once daily.
Children: prucalopride should not be used in children and adolescents younger than 18 years.
Side Effects
Headache is the side effect most often reported with Prucalo, and it affects 17.8% of people. Abdominal pain, nausea and diarrhoea are also common. These reactions mostly happen at the start of treatment and usually go away within a few days if the medicine is continued. Other side effects have been reported now and then. Most of the reactions were mild to moderate in intensity.
Cautions & Contraindications
Warnings & Precautions
Prucalopride is removed from the body mainly through the kidneys. For people with severe renal impairment, the recommended dose is 1 mg. Prucalo should be prescribed with caution in patients with severe hepatic impairment (Child-Pugh class C), because there are only limited data in these patients. If a patient has severe diarrhoea, oral contraceptives may not work as well. An additional contraceptive method is recommended, so that the oral contraception doesn't fail. The tablets contain lactose. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Contraindications
Prucalopride succinate should not be given to people who are hypersensitive to the active substance or to any of the excipients. It is also contraindicated in people with renal impairment who need dialysis.
Pregnancy & Breastfeeding
Prucalopride is not recommended during pregnancy, and women who could become pregnant should use effective contraception while they are on treatment. Animal studies have not shown any direct or indirect harmful effects on pregnancy, embryonal or fetal development, parturition or postnatal development. There are no human data on breastfeeding, so Prucalopride is not recommended for use while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Renal Impairment: For patients with severe renal impairment (GFR <30 ml/min/1.73 m2), the dose of Prucalopride Succinate is 1 mg once daily. Patients with mild to moderate renal impairment don't need a dose adjustment.
Hepatic Impairment: Patients with severe hepatic impairment (Child-Pugh class C) start with 1 mg once daily. The dose may go up to 2 mg if needed to improve efficacy, and only if the 1 mg dose is well tolerated. Patients with mild to moderate hepatic impairment don't need a dose adjustment.
Overdose
Taking too much Prucalopride Succinate can exaggerate the effects the medicine already has on the body. The symptoms include headache, nausea and diarrhoea. There is no specific treatment for an overdose. If it happens, the patient should be treated for the symptoms and given supportive care as needed. If heavy fluid loss occurs through diarrhoea or vomiting, electrolyte disturbances may need to be corrected.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Prucalopride Succinate at room temperature, below 30°C. Leave the desiccant in the bottle, and dispense it in the original bottle.
Drug Interactions
Common questions about Resolax 2 mg
What is Resolax 2 mg Tablet?
Resolax 2 mg Tablet is a medicine that contains Prucalopride Succinate. It is made by Everest Pharmaceuticals Ltd. It belongs to the Osmotic purgatives group of medicines.
What is Resolax used for?
Resolax is used for: Constipation.
What are the side effects of Resolax?
Headache is the side effect most often reported with Prucalo, and it affects 17.8% of people. Abdominal pain, nausea and diarrhoea are also common.
Can I take Resolax during pregnancy or while breastfeeding?
Prucalopride is not recommended during pregnancy, and women who could become pregnant should use effective contraception while they are on treatment. Animal studies have not shown any direct or indirect harmful effects on pregnancy, embryonal or fetal development, parturition or postnatal development. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Resolax?
Taking too much Prucalopride Succinate can exaggerate the effects the medicine already has on the body. The symptoms include headache, nausea and diarrhoea. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Resolax?
Store Prucalopride Succinate at room temperature, below 30°C. Leave the desiccant in the bottle, and dispense it in the original bottle.
Can I take other medicines with Resolax?
Some medicines can interact with Prucalopride Succinate, for example: Cyclosporine, Prucalopride, Ketoconazole, Verapamil Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Resolax is already among the lowest-priced brands of Prucalopride Succinate at this strength.
Do I need a prescription for Resolax?
Resolax is a prescription (Rx) medicine. Take it as your doctor advises.