Indications
Prednisolone Acetate is used for inflammatory conditions that respond to steroids, affecting the palpebral and bulbar conjunctiva, the cornea and the anterior segment of the globe. These include allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis and cyclitis. It is also used in selected infective conjunctivitides, but only when the inherent hazard of steroid use is accepted so that edema and inflammation can be reduced as advised. Prednisolone Acetate is also used for corneal injury from chemical, radiation or thermal burns, or from penetration of foreign bodies.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Prednisolone Acetate is a corticosteroid. Weight for weight, its anti-inflammatory potency is 3 to 5 times that of Hydrocortisone. Corticosteroids inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen and scar formation that go with inflammation.
There is no generally accepted explanation for how ocular corticosteroids work. They are thought to act by inducing phospholipase A2 inhibitory proteins, which are collectively called lipocortins. The idea is that these proteins control the biosynthesis of potent inflammatory mediators such as prostaglandins and leukotrienes, by blocking the release of their common precursor, arachidonic acid. Phospholipase A2 is the enzyme that releases arachidonic acid from membrane phospholipids.
Pregnancy & Breastfeeding
No adequate and well controlled studies have been done in pregnant women. So Prednisolone Acetate ophthalmic suspension should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.
It isn't known whether corticosteroids given as eye drops are absorbed into the body enough to leave detectable amounts in breast milk. For that reason, the medicine should be used by a nursing mother only if the potential benefit justifies the potential risk to the fetus.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.