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Indications & Uses
Prednisolone Acetate is used for inflammatory conditions that respond to steroids, affecting the palpebral and bulbar conjunctiva, the cornea and the anterior segment of the globe. These include allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis and cyclitis. It is also used in selected infective conjunctivitides, but only when the inherent hazard of steroid use is accepted so that edema and inflammation can be reduced as advised. Prednisolone Acetate is also used for corneal injury from chemical, radiation or thermal burns, or from penetration of foreign bodies.
Pharmacology
Prednisolone Acetate is a corticosteroid. Weight for weight, its anti-inflammatory potency is 3 to 5 times that of Hydrocortisone. Corticosteroids inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen and scar formation that go with inflammation.
There is no generally accepted explanation for how ocular corticosteroids work. They are thought to act by inducing phospholipase A2 inhibitory proteins, which are collectively called lipocortins. The idea is that these proteins control the biosynthesis of potent inflammatory mediators such as prostaglandins and leukotrienes, by blocking the release of their common precursor, arachidonic acid. Phospholipase A2 is the enzyme that releases arachidonic acid from membrane phospholipids.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Shake the bottle well before each use. The usual dose of Prednisolone Acetate is 1 drop into the conjunctival sac, two to four times daily. During the first 24 to 48 hours, the doctor may increase how often the drops are used if needed. Take care not to stop the treatment too early.
Side Effects
Side effects of Prednisolone Acetate, from most to least frequent, are a rise in intraocular pressure (IOP) that may lead to glaucoma, optic nerve damage (infrequent), posterior subcapsular cataract formation and delayed wound healing. Preparations that contain corticosteroids have also been reported to cause acute anterior uveitis and perforation of the globe. After local use of corticosteroids, keratitis, conjunctivitis, corneal ulcers, mydriasis, conjunctival hyperemia, loss of accommodation and ptosis have occasionally been reported. In some cases a secondary eye infection has developed, and it may be bacterial, fungal or viral.
Cautions & Contraindications
Warnings & Precautions
If signs and symptoms haven't improved after 2 days, the patient should be re-evaluated. Fungal infections of the cornea tend to develop alongside long-term local corticosteroid use, so fungal invasion should be suspected in any corneal ulcer that persists while a corticosteroid is being used or has been used. Fungal cultures should be taken when appropriate. If Prednisolone Acetate is used for 10 days or longer, intraocular pressure should be monitored. Don't let the dropper tip touch any surface, because this may contaminate Prednisolone Acetate.
Contraindications
Prednisolone Acetate 1% ophthalmic suspension must not be used in most viral diseases of the cornea and conjunctiva. This includes epithelial herpes simplex keratitis (dendritic keratitis), vaccinia and varicella. It is also contraindicated in mycobacterial infection of the eye and in fungal diseases of the ocular structures. And people with known or suspected hypersensitivity to any of the ingredients in this preparation should not use it either.
Pregnancy & Breastfeeding
No adequate and well controlled studies have been done in pregnant women. So Prednisolone Acetate ophthalmic suspension should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.
It isn't known whether corticosteroids given as eye drops are absorbed into the body enough to leave detectable amounts in breast milk. For that reason, the medicine should be used by a nursing mother only if the potential benefit justifies the potential risk to the fetus.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An overdose of Prednisolone Acetate doesn't usually cause acute problems. If someone swallows it by accident, they should drink fluids to dilute it.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Prednisolone Acetate below 30°C, in a dry place, away from light, and don't let it freeze. Once you've opened the bottle, it's best not to use the contents after one month.
Common questions about Precodil 1%
What is Precodil 1% Ophthalmic Suspension?
Precodil 1% Ophthalmic Suspension is a medicine that contains Prednisolone Acetate. It is made by Opsonin Pharma Limited. It belongs to the Glucocorticoids group of medicines.
What is Precodil used for?
Prednisolone Acetate is used for inflammatory conditions that respond to steroids, affecting the palpebral and bulbar conjunctiva, the cornea and the anterior segment of the globe. These include allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis and cyclitis.
What are the side effects of Precodil?
Side effects of Prednisolone Acetate, from most to least frequent, are a rise in intraocular pressure (IOP) that may lead to glaucoma, optic nerve damage (infrequent), posterior subcapsular cataract formation and delayed wound healing. Preparations that contain corticosteroids have also been reported to cause acute anterior uveitis and perforation of the globe.
Can I take Precodil during pregnancy or while breastfeeding?
No adequate and well controlled studies have been done in pregnant women. So Prednisolone Acetate ophthalmic suspension should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Precodil?
An overdose of Prednisolone Acetate doesn't usually cause acute problems. If someone swallows it by accident, they should drink fluids to dilute it. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Precodil?
Keep Prednisolone Acetate below 30°C, in a dry place, away from light, and don't let it freeze. Once you've opened the bottle, it's best not to use the contents after one month.
Do I need a prescription for Precodil?
Precodil is a prescription (Rx) medicine. Take it as your doctor advises.