Indications
Pramipexole tablet is used to treat Parkinson's disease, either on its own or as an add-on to levodopa taken with a dopa-decarboxylase inhibitor. It is also used for moderate to severe restless legs syndrome.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Nobody knows the exact way pramipexole works in Parkinson's disease at this time. One idea is that it stimulates dopamine receptors in the striatum, a part of the brain that receives a vast array of neurological input and is responsible for a wide variety of functions. This may be involved in its effect. Animal studies show that pramipexole changes the rate of striatal neuronal transmission after the dopamine receptors are activated.
Pramipexole is considered a non-ergot dopamine agonist. In vitro, it shows specificity and strong activity at the D2 subfamily of dopamine receptors, binding selectively to dopamine D2 receptors. It also prefers the dopamine D3 receptor subtype over the other subtypes. The clinical significance of this binding specificity is unknown.
Pregnancy & Breastfeeding
Nobody has studied how pramipexole affects pregnancy or breast-feeding in humans. So in pregnancy, pramipexole should be used only if the possible benefit to the mother justifies the possible risk to the foetus. The medicine is known to reduce prolactin secretion in humans. Whether pramipexole passes into breast milk hasn't been studied in women, and for that reason it should not be used while breast-feeding. If its use can't be avoided, breast-feeding should be stopped.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.