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Indications & Uses
Parixol is indicated for:
Pharmacology
Nobody knows the exact way pramipexole works in Parkinson's disease at this time. One idea is that it stimulates dopamine receptors in the striatum, a part of the brain that receives a vast array of neurological input and is responsible for a wide variety of functions. This may be involved in its effect. Animal studies show that pramipexole changes the rate of striatal neuronal transmission after the dopamine receptors are activated.
Pramipexole is considered a non-ergot dopamine agonist. In vitro, it shows specificity and strong activity at the D2 subfamily of dopamine receptors, binding selectively to dopamine D2 receptors. It also prefers the dopamine D3 receptor subtype over the other subtypes. The clinical significance of this binding specificity is unknown.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Pramipexole is dosed differently for Parkinson's disease and for restless legs syndrome.
Parkinson's disease: Start with 88 micrograms 3 times daily. If the patient tolerates it, double the dose every 5 to 7 days until it reaches 350 micrograms 3 times daily. After that, the dose can be raised further if needed, by 180 micrograms 3 times daily at weekly intervals. The maximum is 3.3 mg daily, given in 3 divided doses. While the pramipexole dose is being increased and during maintenance, the Levodopa dose should be reduced.
Restless legs syndrome: Start with 88 micrograms once daily, taken 2 to 3 hours before bedtime. If necessary, double the dose every 4 to 7 days up to 350 micrograms daily. The maximum is 540 micrograms daily.
Use in children: Pramipexole is not recommended for children below 18 years of age.
Side Effects
Common side effects of pramipexole include dizziness, dyskinesia, nausea, hypotension, abnormal dreams, confusion, constipation, delusion, hallucinations and headache. Others are hyperkinesia, increased eating (binge eating, hyperphagia), insomnia, libido disorders, peripheral oedema, paranoia, pathological gambling, hypersexuality and other abnormal behaviour. People may also have somnolence, weight increase, sudden onset of sleep, pruritus, and rash or other hypersensitivity reactions.
Cautions & Contraindications
Warnings & Precautions
Take care when giving pramipexole to patients with a psychotic disorder, severe cardiovascular disease or renal impairment. Regular eye checks (ophthalmologic monitoring) are also recommended during treatment.
Contraindications
Don't give pramipexole to anyone with known hypersensitivity to the active substance or to any of the excipients.
Pregnancy & Breastfeeding
Nobody has studied how pramipexole affects pregnancy or breast-feeding in humans. So in pregnancy, pramipexole should be used only if the possible benefit to the mother justifies the possible risk to the foetus. The medicine is known to reduce prolactin secretion in humans. Whether pramipexole passes into breast milk hasn't been studied in women, and for that reason it should not be used while breast-feeding. If its use can't be avoided, breast-feeding should be stopped.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
There is no clinical experience with a massive overdose of pramipexole. The symptoms of overdose are nausea, vomiting, hyperkinesia, hallucinations, agitation and hypotension. No antidote has been established. If signs of central nervous system stimulation are present, a neuroleptic agent may be indicated. Management may need general supportive measures, along with gastric lavage, intravenous fluids, activated charcoal and electrocardiogram monitoring.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Pramipexole in a cool, dry place and away from light.
Drug Interactions
Common questions about Parixol 88 mcg
What is Parixol 88 mcg Tablet?
Parixol 88 mcg Tablet is a medicine that contains Pramipexole. It is made by Advanced Chemical Industries PLC. It belongs to the Antiparkinson drugs group of medicines.
What is Parixol used for?
Parixol is used for: Parkinson's Disease.
What are the side effects of Parixol?
Common side effects of pramipexole include dizziness, dyskinesia, nausea, hypotension, abnormal dreams, confusion, constipation, delusion, hallucinations and headache. Others are hyperkinesia, increased eating (binge eating, hyperphagia), insomnia, libido disorders, peripheral oedema, paranoia, pathological gambling, hypersexuality and other abnormal behaviour.
Can I take Parixol during pregnancy or while breastfeeding?
Nobody has studied how pramipexole affects pregnancy or breast-feeding in humans. So in pregnancy, pramipexole should be used only if the possible benefit to the mother justifies the possible risk to the foetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Parixol?
There is no clinical experience with a massive overdose of pramipexole. The symptoms of overdose are nausea, vomiting, hyperkinesia, hallucinations, agitation and hypotension. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Parixol?
Keep Pramipexole in a cool, dry place and away from light.
Can I take other medicines with Parixol?
Some medicines can interact with Pramipexole, for example: Cimetidine, Amantadine Hydrochloride, Dopamine Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Parixol is already among the lowest-priced brands of Pramipexole at this strength.
Do I need a prescription for Parixol?
Parixol is a prescription (Rx) medicine. Take it as your doctor advises.