Informational only — Not medical advice. Always consult a licensed healthcare provider.

Shasthya স্বাস্থ্য · Health, made simple
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Community data Updated 23 hours ago
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Indications

Eczema

Pimecrolimus Cream is a second-line treatment for mild to moderate atopic dermatitis. Doctors use it for short-term treatment and for noncontinuous treatment of long-lasting (chronic) disease. It is meant for adults and for children 2 years of age and older who are not immunocompromised. It is given when other topical prescription treatments haven't worked well enough, or when those treatments are not advisable.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Nobody knows exactly how Pimecrolimus works in atopic dermatitis. What has been shown is that it binds to macrophilin-12 (FKBP-12) and blocks calcineurin, a calcium-dependent phosphatase. This stops T cells from being activated.

More specifically, Pimecrolimus blocks the synthesis of several cytokines in human T cells. These are Interleukin-2 and Interferon gamma (Th1-type), and Interleukin-4 and Interleukin-10 (Th2-type). In vitro, Pimecrolimus also stops mast cells from releasing inflammatory cytokines and mediators after they are stimulated by antigen/IgE.

Pregnancy & Breastfeeding

Pimecrolimus is Pregnancy Category C. Nobody knows yet whether the components of the preparation pass into human milk. Pimecrolimus and breastfeeding should not be continued together at the same time.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Clean the skin before you apply Pimecrolimus cream. Use one finger tip unit (that is the distance from the tip of an adult index finger to the first crease of that finger) and spread it thinly and evenly over the affected skin twice daily. Stop the treatment once the signs and symptoms, such as itch, rash and redness, clear up. If they persist beyond 6 weeks, the patient should be re-examined so the diagnosis of atopic dermatitis can be confirmed. During treatment with Pimecrolimus Cream, the patient should not use sun lamps or tanning beds, and should not have ultraviolet light therapy. Continuous long-term use of Pimecrolimus should be avoided. The treated skin should not be covered with bandages, dressings or wraps. Loose fitting clothing that protects the treated area from the sun is encouraged. Use in Children and Adolescents Pimecrolimus cream is not indicated for children less than 2 years of age.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.