Pricing
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All price changes →Indications & Uses
Pmec is indicated for:
Pharmacology
Nobody knows exactly how Pimecrolimus works in atopic dermatitis. What has been shown is that it binds to macrophilin-12 (FKBP-12) and blocks calcineurin, a calcium-dependent phosphatase. This stops T cells from being activated.
More specifically, Pimecrolimus blocks the synthesis of several cytokines in human T cells. These are Interleukin-2 and Interferon gamma (Th1-type), and Interleukin-4 and Interleukin-10 (Th2-type). In vitro, Pimecrolimus also stops mast cells from releasing inflammatory cytokines and mediators after they are stimulated by antigen/IgE.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Clean the skin before you apply Pimecrolimus cream. Use one finger tip unit (that is the distance from the tip of an adult index finger to the first crease of that finger) and spread it thinly and evenly over the affected skin twice daily. Stop the treatment once the signs and symptoms, such as itch, rash and redness, clear up. If they persist beyond 6 weeks, the patient should be re-examined so the diagnosis of atopic dermatitis can be confirmed.
During treatment with Pimecrolimus Cream, the patient should not use sun lamps or tanning beds, and should not have ultraviolet light therapy. Continuous long-term use of Pimecrolimus should be avoided. The treated skin should not be covered with bandages, dressings or wraps. Loose fitting clothing that protects the treated area from the sun is encouraged.
Use in Children and Adolescents
Pimecrolimus cream is not indicated for children less than 2 years of age.
Side Effects
Pimecrolimus can cause burning or a feeling of warmth where it is applied. These effects are usually mild or moderate, they tend to show up in the first few days of treatment, and they usually clear up within a few days. Other side effects are uncommon, and may include headache, common cold or stuffy nose, sore throat, cough, flu (influenza), fever and viral infection.
Cautions & Contraindications
Warnings & Precautions
Don't use Pimecrolimus Cream on malignant or pre-malignant skin conditions, such as cutaneous T-cell lymphoma (CTCL). Also avoid it in Netherton's Syndrome, in bacterial and viral skin infections, and in other skin diseases where more Pimecrolimus could be absorbed into the body. Keep the cream out of the eyes, nose, mouth, vagina and rectum (the mucous membranes).
Contraindications
Pimecrolimus cream must not be used by anyone who has had an allergic reaction to Pimecrolimus, or to any other ingredient in the cream.
Pregnancy & Breastfeeding
Pimecrolimus is Pregnancy Category C. Nobody knows yet whether the components of the preparation pass into human milk. Pimecrolimus and breastfeeding should not be continued together at the same time.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
There's no data on what happens when a patient takes too much Pimecrolimus. If an overdose is suspected, get medical help immediately.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Pimecrolimus below 30°C, in a dry place and away from light. Make sure children can't reach it.
Drug Interactions
Common questions about Pmec 1%
What is Pmec 1% Cream?
Pmec 1% Cream is a medicine that contains Pimecrolimus. It is made by Navana Pharmaceuticals Ltd. It belongs to the Drugs affecting the immune response group of medicines.
What is Pmec used for?
Pmec is used for: Eczema.
What are the side effects of Pmec?
Pimecrolimus can cause burning or a feeling of warmth where it is applied. These effects are usually mild or moderate, they tend to show up in the first few days of treatment, and they usually clear up within a few days.
Can I take Pmec during pregnancy or while breastfeeding?
Pimecrolimus is Pregnancy Category C. Nobody knows yet whether the components of the preparation pass into human milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Pmec?
There's no data on what happens when a patient takes too much Pimecrolimus. If an overdose is suspected, get medical help immediately. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Pmec?
Keep Pimecrolimus below 30°C, in a dry place and away from light. Make sure children can't reach it.
Can I take other medicines with Pmec?
Some medicines can interact with Pimecrolimus, for example: Erythromycin, Fluconazole, Itraconazole, Cimetidine, Ketoconazole. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Pmec?
Pmec is a prescription (Rx) medicine. Take it as your doctor advises.