Permethrin + Crotamiton

Indications

Eczema Urticaria Scabies

Permethrin + Crotamiton lotion is used to treat scabies and pruritus. It also relieves itching and skin irritation from sunburn, dry eczema, itchy dermatitis, allergic rashes, hives, nettle rash, chickenpox, insect bites and stings, heat rashes and personal itching.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

This medicine is a combination of Permethrin and Crotamiton. Permethrin is a photostable synthetic pyrethroid with broad insecticidal activity and low toxicity in mammals. Crotamiton is used to treat scabies infection, and it is also used to relieve the itching of certain skin conditions.

Mode of action: An insect absorbs Permethrin quickly through its mouth, respiratory tract or the intact cuticle. The nervous system is the main target tissue, but the insect isn't killed by the failure of a single organ. Death comes from a complex series of reactions in various organs, such as metabolic exhaustion and paralysis of the nervous system. Permethrin mainly affects the sodium channels in the nerve membrane. It prolongs the transient increase in sodium permeability that goes with membrane depolarization. After treatment with permethrin, the sodium current is evoked by a step depolarization of the membrane. This leads to sensory hyperexcitability, incoordination and prostration. The mode of action against mites is assumed to be similar.

Pharmacokinetics: The only approved route is topical, and there are few human data on systemic exposure or kinetics after permethrin is applied to the skin. Some presystemic metabolism occurs in the skin. Less than 0.5% of applied permethrin is absorbed during the first 48 hours. Absorbed permethrin is rapidly metabolized by ester hydrolysis, most likely in the liver, and the products are excreted mainly in the urine. Crotamiton penetrates quickly into human skin. Low but measurable concentrations of crotamiton are found in plasma, with a maximum level after 4 to 10 hours, and the level then declines rapidly.

Pregnancy & Breastfeeding

We don't have enough experience to judge whether Permethrin and Crotamiton is safe in pregnancy, so it isn't recommended during pregnancy, and especially not in the first three months. It isn't known whether the active substance passes into breast milk. If you are nursing, avoid applying it around the nipples.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: For adults, including the elderly, the patient should first take a warm bath and dry the skin well. Permethrin + Crotamiton is then rubbed into the whole body surface, leaving out the face and scalp, until no trace of the preparation can be seen on the skin. Repeat this once daily, preferably in the evening, for a total of 3 to 5 days. Depending on the response, take special care over the sites mites infest most easily, such as the interdigital spaces, wrists, axillae and genitalia. Areas where pus has formed should be covered with a dressing soaked in the lotion. While treatment is going on, the patient may bathe shortly before the next application. Once treatment is finished, the patient should take a cleansing bath and then change the bed linen and underclothing. For children, apply the lotion as described for adults, but in children under 2 years don't apply it more than once a day. Before each application the skin should be clean, cool and dry. In adults and children over 2 years, apply the lotion to the whole body from the neck down and rub it in lightly until it disappears. Include every skin surface, such as between the fingers and toes, under the nails and on the soles of the feet. For babies under 2 years, apply it to the face, neck, ears and scalp as well, avoiding only the area immediately around the eyes and mouth. Leave the lotion on for at least 8 hours before washing it off. If any area gets washed during the 8 hours of treatment (after washing the hands, for example), apply the lotion to it again.

Suggest a correction

Permethrin + Crotamiton

Indications

Pharmacology

Pregnancy & Breastfeeding

Dosage Reference

Side Effects & Interactions

Side Effects

Key Interactions