Pricing
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Pharmacology
This medicine is a combination of Permethrin and Crotamiton. Permethrin is a photostable synthetic pyrethroid with broad insecticidal activity and low toxicity in mammals. Crotamiton is used to treat scabies infection, and it is also used to relieve the itching of certain skin conditions.
Mode of action: An insect absorbs Permethrin quickly through its mouth, respiratory tract or the intact cuticle. The nervous system is the main target tissue, but the insect isn't killed by the failure of a single organ. Death comes from a complex series of reactions in various organs, such as metabolic exhaustion and paralysis of the nervous system. Permethrin mainly affects the sodium channels in the nerve membrane. It prolongs the transient increase in sodium permeability that goes with membrane depolarization. After treatment with permethrin, the sodium current is evoked by a step depolarization of the membrane. This leads to sensory hyperexcitability, incoordination and prostration. The mode of action against mites is assumed to be similar.
Pharmacokinetics: The only approved route is topical, and there are few human data on systemic exposure or kinetics after permethrin is applied to the skin. Some presystemic metabolism occurs in the skin. Less than 0.5% of applied permethrin is absorbed during the first 48 hours. Absorbed permethrin is rapidly metabolized by ester hydrolysis, most likely in the liver, and the products are excreted mainly in the urine. Crotamiton penetrates quickly into human skin. Low but measurable concentrations of crotamiton are found in plasma, with a maximum level after 4 to 10 hours, and the level then declines rapidly.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For adults, including the elderly, the patient should first take a warm bath and dry the skin well. Permethrin + Crotamiton is then rubbed into the whole body surface, leaving out the face and scalp, until no trace of the preparation can be seen on the skin. Repeat this once daily, preferably in the evening, for a total of 3 to 5 days. Depending on the response, take special care over the sites mites infest most easily, such as the interdigital spaces, wrists, axillae and genitalia. Areas where pus has formed should be covered with a dressing soaked in the lotion. While treatment is going on, the patient may bathe shortly before the next application. Once treatment is finished, the patient should take a cleansing bath and then change the bed linen and underclothing.
For children, apply the lotion as described for adults, but in children under 2 years don't apply it more than once a day. Before each application the skin should be clean, cool and dry. In adults and children over 2 years, apply the lotion to the whole body from the neck down and rub it in lightly until it disappears. Include every skin surface, such as between the fingers and toes, under the nails and on the soles of the feet. For babies under 2 years, apply it to the face, neck, ears and scalp as well, avoiding only the area immediately around the eyes and mouth. Leave the lotion on for at least 8 hours before washing it off. If any area gets washed during the 8 hours of treatment (after washing the hands, for example), apply the lotion to it again.
Side Effects
In people being treated for scabies, a few feel skin discomfort soon after the Permethrin and Crotamiton lotion is applied. They usually describe it as burning, stinging or tingling. Other short-lived signs of irritation can follow treatment too, such as erythema, edema, eczema and rash, but these are generally considered part of the natural history of scabies itself.
Cautions & Contraindications
Warnings & Precautions
Nursing staff who apply Permethrin and Crotamiton lotion regularly may wear gloves, so the lotion doesn't irritate their hands. Keep the lotion away from the eyes, because it can cause eye irritation. If any gets into the eye, rinse with water straight away.
Contraindications
Permethrin and Crotamiton lotion should not be used by anyone who is known to be allergic to permethrin or to any of its components. The same applies to people who are allergic to other pyrethroids or pyrethrins.
Pregnancy & Breastfeeding
We don't have enough experience to judge whether Permethrin and Crotamiton is safe in pregnancy, so it isn't recommended during pregnancy, and especially not in the first three months. It isn't known whether the active substance passes into breast milk. If you are nursing, avoid applying it around the nipples.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
No overdose has been reported with Permethrin and Crotamiton lotion. Still, applying too much of the lotion could cause local reactions at the site, or more severe skin reactions.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Permethrin + Crotamiton out of reach of children. Store it in a dry place, below 25°C, and protect it from light.
Drug Interactions
Common questions about Crotam Plus 5%+10%
What is Crotam Plus 5%+10% Lotion?
Crotam Plus 5%+10% Lotion is a medicine that contains Permethrin + Crotamiton. It is made by Ethical Drug Ltd. It belongs to the Local Antipruritic group of medicines.
What is Crotam Plus used for?
Crotam Plus is used for: Eczema, Urticaria, Scabies.
What are the side effects of Crotam Plus?
In people being treated for scabies, a few feel skin discomfort soon after the Permethrin and Crotamiton lotion is applied. They usually describe it as burning, stinging or tingling.
Can I take Crotam Plus during pregnancy or while breastfeeding?
We don't have enough experience to judge whether Permethrin and Crotamiton is safe in pregnancy, so it isn't recommended during pregnancy, and especially not in the first three months. It isn't known whether the active substance passes into breast milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Crotam Plus?
No overdose has been reported with Permethrin and Crotamiton lotion. Still, applying too much of the lotion could cause local reactions at the site, or more severe skin reactions. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Crotam Plus?
Keep Permethrin + Crotamiton out of reach of children. Store it in a dry place, below 25°C, and protect it from light.
Can I take other medicines with Crotam Plus?
Some medicines can interact with Permethrin + Crotamiton, for example: Crotamiton, Permethrin. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Crotam Plus?
Crotam Plus is a prescription (Rx) medicine. Take it as your doctor advises.