Indications
Pentosan Polysulfate Sodium is used to relieve bladder pain or discomfort that comes with interstitial cystitis.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Pentosan polysulfate is a polymer of xylose hydrogen sulfate, with two sulfate groups on each carbohydrate monomer. It binds Fibroblast growth factors (FGFs) and other heparin-binding growth factors, and it has also been shown to interact with the heparin-binding site of FGFR-1. In laboratory work, pentosan polysulfate inhibits the growth of SW13 adrenocortical cells transfected with FGF-4. It also inhibits the tumorigenicity of MCF-7 breast carcinoma cells transfected with FGF-1 or FGF-4.
Pregnancy & Breastfeeding
Pregnancy
Pentosan Polysulfate Sodium has been tested in animals. Mice and rats were given 15 mg/kg intravenously every day, and rabbits were given 7.5 mg/kg. Compared with the daily oral dose in humans, and adjusted for body surface area, these doses were 0.42 and 0.14 times as high. The studies showed no sign of reduced fertility or harm to the fetus.
In a separate laboratory test, cultured mouse embryos were bathed directly in pentosan polysulfate sodium (PPS) at a concentration of 1 mg/mL. This may cause reversible limb bud abnormalities.
No adequate, well-controlled studies have been done in pregnant women. Animal studies don't always predict how humans will respond, so the medicine should be used in pregnancy only if clearly needed.
Nursing mothers
It isn't known whether this medicine passes into human milk. Many drugs do, so caution is needed when Pentosan Polysulfate Sodium is given to a breastfeeding woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.