Pricing
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All price changes →Indications & Uses
Thrombocid is indicated for:
Pharmacology
Pentosan polysulfate is a polymer of xylose hydrogen sulfate, with two sulfate groups on each carbohydrate monomer. It binds Fibroblast growth factors (FGFs) and other heparin-binding growth factors, and it has also been shown to interact with the heparin-binding site of FGFR-1. In laboratory work, pentosan polysulfate inhibits the growth of SW13 adrenocortical cells transfected with FGF-4. It also inhibits the tumorigenicity of MCF-7 breast carcinoma cells transfected with FGF-1 or FGF-4.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dose of Pentosan Polysulfate Sodium is 300 mg a day, taken as one 100 mg capsule by mouth three times daily. Swallow the capsules with water, at least 1 hour before meals or 2 hours after meals.
Patients taking Pentosan Polysulfate Sodium should be reassessed after 3 months. If there's no improvement and no limiting adverse events, the treatment may go on for another 3 months. For patients whose pain hasn't improved by 6 months, the clinical value and risks of carrying on with treatment are not known.
Pediatric Use: Safety and effectiveness in patients below the age of 16 years have not been established.
Side Effects
Pentosan Polysulfate Sodium was studied in clinical trials with a total of 2,627 patients. Of these, 2,343 were women, 262 were men and 22 were unknown. The mean age was 47 years (range: 18 to 88), and 581 patients (22%) were over 60 years of age. In all, 128 patients took part in a 3-month trial, and the other 2,499 were enrolled in a long-term, unblinded trial. Deaths occurred in 6 out of 2,627 (0.2%) patients who received the drug over a period of 3 to 75 months. They appear to be related to other illnesses or procedures the patients had at the same time. The exception was one patient, whose cause of death was unknown. Adverse Experience in Placebo-Controlled Clinical Trials of Pentosan Polysulfate Sodium 100 mg Three Times a Day for 3 Months The trials showed adverse experiences, including bleeding events and raised liver function tests, particularly at higher doses.
Cautions & Contraindications
Warnings & Precautions
Pentosan Polysulfate Sodium is a weak anticoagulant, with 1/15 the activity of heparin. In patients taking a daily dose of 300 mg (n=128), rectal hemorrhage was reported as an adverse event in 6.3% of them. Other bleeding problems have also been reported, including ecchymosis, epistaxis and gum hemorrhage. Some patients should be evaluated for hemorrhage: those undergoing invasive procedures, those with signs or symptoms of an underlying coagulopathy, and those at higher risk of bleeding because of other therapies such as coumarin anticoagulants, heparin, t-PA, streptokinase, high dose aspirin or nonsteroidal anti inflammatory drugs. Patients with diseases such as aneurysms, thrombocytopenia, hemophilia, gastrointestinal ulcerations, polyps or diverticula need careful evaluation before Pentosan Polysulfate Sodium is started. A similar product, given subcutaneously, sublingually or intramuscularly (so not metabolized by the liver first), is linked with delayed immunoallergic thrombocytopenia, with symptoms of thrombosis and hemorrhage. Use Pentosan Polysulfate Sodium with caution in patients who have a history of heparin induced thrombocytopenia. Alopecia is linked with pentosan polysulfate and also with heparin products. In clinical trials, it began within the first 4 weeks of treatment. Ninety-seven percent (97%) of the reported cases were alopecia areata, limited to a single area on the scalp.
Contraindications
Pentosan Polysulfate Sodium should not be given to patients who are known to be hypersensitive to the drug itself, to compounds with a similar structure, or to any of the excipients in the product.
Pregnancy & Breastfeeding
Pregnancy
Pentosan Polysulfate Sodium has been tested in animals. Mice and rats were given 15 mg/kg intravenously every day, and rabbits were given 7.5 mg/kg. Compared with the daily oral dose in humans, and adjusted for body surface area, these doses were 0.42 and 0.14 times as high. The studies showed no sign of reduced fertility or harm to the fetus.
In a separate laboratory test, cultured mouse embryos were bathed directly in pentosan polysulfate sodium (PPS) at a concentration of 1 mg/mL. This may cause reversible limb bud abnormalities.
No adequate, well-controlled studies have been done in pregnant women. Animal studies don't always predict how humans will respond, so the medicine should be used in pregnancy only if clearly needed.
Nursing mothers
It isn't known whether this medicine passes into human milk. Many drugs do, so caution is needed when Pentosan Polysulfate Sodium is given to a breastfeeding woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
No cases of overdose with Pentosan Polysulfate Sodium have been reported. Going by how the drug works in the body, toxicity would probably show up as anticoagulation, bleeding, thrombocytopenia, liver function abnormalities and gastric distress. In one clinical trial, patients (n=127) received 900 mg daily for 32 weeks, and rectal hemorrhage was reported as an adverse event in 15% of them. Another trial gave Pentosan Polysulfate Sodium 900 mg daily for 16 weeks. There, elevated liver function tests were seen in 11.8% of patients in the Pentosan Polysulfate Sodium group and 2% in the placebo group. If acute overdosage does happen, gastric lavage should be done if possible. The patient should be watched carefully and given symptomatic and supportive treatment.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Pentosan Polysulfate Sodium below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Thrombocid 15 mg
What is Thrombocid 15 mg Topical Gel?
Thrombocid 15 mg Topical Gel is a medicine that contains Pentosan Polysulfate Sodium. It is made by ZAS Corporation. It belongs to the Other genito-urinary preparations group of medicines.
What is Thrombocid used for?
Thrombocid is used for: Pain, Urinary Tract Infection.
What are the side effects of Thrombocid?
Pentosan Polysulfate Sodium was studied in clinical trials with a total of 2,627 patients. Of these, 2,343 were women, 262 were men and 22 were unknown.
Can I take Thrombocid during pregnancy or while breastfeeding?
Pregnancy Pentosan Polysulfate Sodium has been tested in animals. Mice and rats were given 15 mg/kg intravenously every day, and rabbits were given 7.5 mg/kg. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Thrombocid?
No cases of overdose with Pentosan Polysulfate Sodium have been reported. Going by how the drug works in the body, toxicity would probably show up as anticoagulation, bleeding, thrombocytopenia, liver function abnormalities and gastric distress. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Thrombocid?
Store Pentosan Polysulfate Sodium below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Thrombocid?
Some medicines can interact with Pentosan Polysulfate Sodium, for example: Warfarin Sodium. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Thrombocid?
Thrombocid is a prescription (Rx) medicine. Take it as your doctor advises.