Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 23 hours ago

Indications

Pefloxacin Mesylate Dihydrate is indicated in adults for the treatment of a single infection, or mixed infections caused by two or more susceptible microorganisms. It can also be used when the infection is caused by organisms that are resistant to other antibiotics. Pefloxacin Mesylate Dihydrate is indicated for the following conditions. Gastrointestinal infection: enteric fever, acute bacterial diarrhoea and chronic Salmonella carriers. Urinary tract infection: cystitis, pyelonephritis, prostatitis, epididymitis, and uncomplicated and complicated urethritis. Respiratory tract infection: pneumonia, acute and chronic bronchitis, cystic fibrosis, bronchiectasis and empyema. Ear, nose and throat infection: otitis media, otitis externa, sinusitis and tonsillitis. Bone and joint infection: osteomyelitis and arthritis. Skin and soft tissue infection: infected ulcer, wound infection, abscess, cellulitis, erysipelas and infected burn. Pelvic infection: salpingitis, endometritis and pelviperitonitis. Abdominal and hepatobiliary infection: peritonitis, intra abdominal abscess, cholingitis, cholecystitis and empyema of the gall bladder. It is also used in septicemia, bacteraemia, gonorrhoea, endocarditis and meningitis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Pefloxcin is a synthetic antibacterial medicine that belongs to the fluoroquinolone group. It works by inhibiting the subunit-A of DNA gyrase (Topoisomerase II). Pefloxcin kills bacteria, which makes it bactericidal, and it acts against a broad spectrum of them.

Pregnancy & Breastfeeding

The FDA has placed pefloxacin in pregnancy category C.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adults with normal liver function take one Pefloxcin 400 mg tablet every 12 hours, in the morning and evening, with meals so the stomach isn't upset. A first loading dose of 800 mg may be given if the doctor wants an effective blood level reached more quickly. For adults with hepatic insufficiency, the daily doses should be readjusted by lengthening the gap between doses. This applies to patients with severe hepatic insufficiency or reduced blood supply to the liver. The dose does not need to be reduced in renal insufficiency. Duration of Treatment Treatment usually lasts 5 to 10 days. For chronic prostatitis, cystic fibrosis and chronic Salmonella carriers, it is 14 days. For endocarditis, it can go up to 6 months, and for chronic osteomyelitis up to 1 year. For gonorrhoea, the dose is 2 tablets as a single dose.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.

Key Interactions

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