Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →Indications & Uses
Pefloxacin Mesylate Dihydrate is indicated in adults for the treatment of a single infection, or mixed infections caused by two or more susceptible microorganisms. It can also be used when the infection is caused by organisms that are resistant to other antibiotics. Pefloxacin Mesylate Dihydrate is indicated for the following conditions. Gastrointestinal infection: enteric fever, acute bacterial diarrhoea and chronic Salmonella carriers. Urinary tract infection: cystitis, pyelonephritis, prostatitis, epididymitis, and uncomplicated and complicated urethritis. Respiratory tract infection: pneumonia, acute and chronic bronchitis, cystic fibrosis, bronchiectasis and empyema. Ear, nose and throat infection: otitis media, otitis externa, sinusitis and tonsillitis. Bone and joint infection: osteomyelitis and arthritis. Skin and soft tissue infection: infected ulcer, wound infection, abscess, cellulitis, erysipelas and infected burn. Pelvic infection: salpingitis, endometritis and pelviperitonitis. Abdominal and hepatobiliary infection: peritonitis, intra abdominal abscess, cholingitis, cholecystitis and empyema of the gall bladder. It is also used in septicemia, bacteraemia, gonorrhoea, endocarditis and meningitis.
Pharmacology
Pefloxcin is a synthetic antibacterial medicine that belongs to the fluoroquinolone group. It works by inhibiting the subunit-A of DNA gyrase (Topoisomerase II). Pefloxcin kills bacteria, which makes it bactericidal, and it acts against a broad spectrum of them.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults with normal liver function take one Pefloxcin 400 mg tablet every 12 hours, in the morning and evening, with meals so the stomach isn't upset. A first loading dose of 800 mg may be given if the doctor wants an effective blood level reached more quickly.
For adults with hepatic insufficiency, the daily doses should be readjusted by lengthening the gap between doses. This applies to patients with severe hepatic insufficiency or reduced blood supply to the liver. The dose does not need to be reduced in renal insufficiency.
Duration of Treatment
Treatment usually lasts 5 to 10 days. For chronic prostatitis, cystic fibrosis and chronic Salmonella carriers, it is 14 days. For endocarditis, it can go up to 6 months, and for chronic osteomyelitis up to 1 year. For gonorrhoea, the dose is 2 tablets as a single dose.
Side Effects
Pefloxacin Mesylate Dihydrate can occasionally cause a few reactions. These are grouped below by the part of the body they affect. Gastrointestinal disturbance: epigastric pain, nausea, vomiting, diarrhoea and dyspepsia. Central nervous system disturbance: headache and insomnia. Hypersensitivity reaction: skin rash, pruritis and photosensitization. Others: myalgia and/or arthralgia, tendonitis, and rupture of the achilles tendon.
Cautions & Contraindications
Warnings & Precautions
Pefloxacin Mesylate Dihydrate can make the skin react badly to light, so avoid sunlight and ultraviolet radiation while you are on the treatment. If the liver is severely impaired, the dose has to be adjusted. Patients should also be told that pain in the achilles tendon may happen.
Contraindications
Pefloxacin should not be given to anyone with a known allergy to quinolones. It is also contraindicated in children under 15 years of age, and in pregnant and breastfeeding mothers. Patients with inborn glucose-6-phosphate dehydrogenase deficiency should not take it, and neither should those who have had a tendon lesion, tendonitis or tendon rupture in the past.
Pregnancy & Breastfeeding
The FDA has placed pefloxacin in pregnancy category C.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Pefloxacin Mesylate Dihydrate below 30°C, away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Nobac 400 mg
What is Nobac 400 mg Tablet?
Nobac 400 mg Tablet is a medicine that contains Pefloxacin Mesylate Dihydrate. It is made by Ibn Sina Pharmaceutical Ind. Ltd. It belongs to the 4-Quinolone preparations group of medicines.
What is Nobac used for?
Pefloxacin Mesylate Dihydrate is indicated in adults for the treatment of a single infection, or mixed infections caused by two or more susceptible microorganisms. It can also be used when the infection is caused by organisms that are resistant to other antibiotics.
What are the side effects of Nobac?
Pefloxacin Mesylate Dihydrate can occasionally cause a few reactions. These are grouped below by the part of the body they affect.
Can I take Nobac during pregnancy or while breastfeeding?
The FDA has placed pefloxacin in pregnancy category C. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Nobac?
Store Pefloxacin Mesylate Dihydrate below 30°C, away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Nobac?
Some medicines can interact with Pefloxacin Mesylate Dihydrate, for example: Magnesium Hydroxide. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Nobac is already among the lowest-priced brands of Pefloxacin Mesylate Dihydrate at this strength.
Do I need a prescription for Nobac?
Nobac is a prescription (Rx) medicine. Take it as your doctor advises.