Indications
Olopatadine Hydrochloride eye drops are used to treat the signs and symptoms of allergic conjunctivitis. These are itchy, watery, red and swollen eyes and/or eyelids. The use includes vernal keratoconjunctivitis, vernal keratitis, blepharitis, blepharoconjunctivitis and giant papillary conjunctivitis. Olodin DS eye drops is used for the same purpose: the signs and symptoms (itchy, watery, red and swollen eyes and/or eyelids) of allergic conjunctivitis, including vernal keratoconjunctivitis, vernal keratitis, blepharitis, blepharoconjunctivitis and giant papillary conjunctivitis. Olopatadine Hydrochloride Nasal Spray is used to relieve the symptoms of seasonal allergic rhinitis in adults and children 6 years of age and older. Olopatadine Hydrochloride tablet is used to treat allergic rhinitis (swelling of the nasal membranes caused by an allergy to pollen and mold spores in the air) and allergic skin conditions. It helps relieve allergy symptoms such as skin rashes, swelling, hives (itchy, painful eruptions that sting), itching, sneezing, and a runny or stuffy nose.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Olopatadine is an antihistamine. It blocks the action of histamine in the body, and that reduces allergy symptoms. Olopatadine hydrochloride treats sneezing, itching, runny nose and other nasal symptoms of allergies.
Mode of Action: Olopatadine is an anti-allergic molecule that works in several ways. As a mast cell stabilizer, it stabilizes rodent basophils and human conjunctival mast cells and inhibits the immunologically-stimulated release of histamine. It also acts as an antagonist at the histamine H1 receptors, with high selectivity. Upon binding, it blocks the H1 receptor signaling pathway. This stops the release of inflammatory mediators such as tryptase, prostaglandin D2 and TNF-alpha, as well as pro-inflammatory cytokines.
Pharmacokinetics: Absorption: Olopatadine was absorbed, and individual peak plasma concentrations were seen between 30 minutes and 1 hour after twice daily intranasal administration of Olopatadine Nasal Spray. Distribution: Protein binding was moderate, at approximately 55% in human serum, and it did not depend on drug concentration over the range of 0.1 to 1000 ng/mL. Metabolism: The body does not metabolize olopatadine extensively. Plasma metabolite profiles show that at least six minor metabolites circulate in human plasma. Elimination: The plasma elimination half-life is 8 to 12 hours. Olopatadine is mainly eliminated through urinary excretion.
Pregnancy & Breastfeeding
Olopatadine did not cause birth defects (it was found not to be teratogenic) in studies on rats and rabbits. But there are no adequate and well controlled studies in pregnant women. So Olopatadine should be used in pregnancy only if the possible benefit justifies the possible risk to the fetus.
It isn't known whether eye drops put on the surface of the eye can be absorbed into the body enough to leave detectable amounts in human breast milk. Even so, a nursing mother should take caution when using Olopatadine.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.