More from Opatin
Other strengths and forms by Opsonin Pharma Limited
Indications & Uses
Opatin is indicated for:
Pharmacology
Olopatadine is an antihistamine. It blocks the action of histamine in the body, and that reduces allergy symptoms. Olopatadine hydrochloride treats sneezing, itching, runny nose and other nasal symptoms of allergies.
Mode of Action: Olopatadine is an anti-allergic molecule that works in several ways. As a mast cell stabilizer, it stabilizes rodent basophils and human conjunctival mast cells and inhibits the immunologically-stimulated release of histamine. It also acts as an antagonist at the histamine H1 receptors, with high selectivity. Upon binding, it blocks the H1 receptor signaling pathway. This stops the release of inflammatory mediators such as tryptase, prostaglandin D2 and TNF-alpha, as well as pro-inflammatory cytokines.
Pharmacokinetics: Absorption: Olopatadine was absorbed, and individual peak plasma concentrations were seen between 30 minutes and 1 hour after twice daily intranasal administration of Olopatadine Nasal Spray. Distribution: Protein binding was moderate, at approximately 55% in human serum, and it did not depend on drug concentration over the range of 0.1 to 1000 ng/mL. Metabolism: The body does not metabolize olopatadine extensively. Plasma metabolite profiles show that at least six minor metabolites circulate in human plasma. Elimination: The plasma elimination half-life is 8 to 12 hours. Olopatadine is mainly eliminated through urinary excretion.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
administer Olopatadine Nasal Spray by the intranasal route only. Adults and adolescents 12 years of age and older use two sprays per nostril twice daily. Children 6 to 11 years of age use one spray per nostril twice daily.
Dosage for other forms (2)
Eye drops (0.1%): put one drop in each affected eye twice a day, with 6 to 8 hours between the doses. For the 0.2% strength, use one drop in the affected eye once a day. The 0.7% strength is also one drop once a day, but in each affected eye.
adults take 1 tablet (5 mg of the active ingredient) at a time, twice daily, in the morning and before going to bed. The doctor may adjust the dose according to the disease, age or symptoms. Children 7 years old or over also take 1 tablet (5 mg) at a time, twice daily, in the morning and before going to bed.
If you miss a dose, take it as soon as you remember. But if it's almost time for the next dose, skip the missed one and follow your regular schedule. Never take two doses at one time. Don't stop taking this medicine unless your doctor tells you to.
Side Effects
Headaches have been reported with Olopatadine Hydrochloride, though rarely. Other side effects that have been reported are asthenia, blurred vision, burning or stinging, cold syndrome, dry eye, a feeling of something foreign in the eye, hyperemia, hypersensitivity, keratitis, lid edema, nausea, pharyngitis, pruritus, rhinitis, sinusitis and taste perversion.
Cautions & Contraindications
Warnings & Precautions
Patients should be told not to wear contact lenses if their eyes are red. Olopatadine Hydrochloride eye drops should not be used to treat irritation caused by contact lenses. Patadin contains benzalkonium chloride as a preservative, and soft contact lenses may absorb it. If a patient wears soft contact lenses and their eyes are not red, they should wait at least 10 minutes after putting in Patadin eye drops before inserting the lenses. Stop the treatment if an allergic reaction appears. For the nasal spray, prime it before first use by releasing 5 sprays, or until a fine mist appears. If Olopatadine Hydrochloride Nasal Spray hasn't been used for more than 7 days, prime it again by releasing 2 sprays. Don't spray it into the eyes, and patients should be told this as well. Olopatadine Hydrochloride Tablet should be taken as your doctor has prescribed. Take it at the same time every day, so that the level of the medicine in your body stays constant. Don't take more than the recommended dose. Don't stop taking it without talking to your doctor, because your symptoms may come back.
Contraindications
Olopatadine Hydrochloride must not be used by anyone who is known to be hypersensitive to any component of the product. If you're allergic to it, the Olopatadine 5 mg tablet isn't recommended for you. Tell your doctor which medicines you are taking now and what other medical conditions you already have, so that they can make sure this medicine is safe for you.
Pregnancy & Breastfeeding
Olopatadine did not cause birth defects (it was found not to be teratogenic) in studies on rats and rabbits. But there are no adequate and well controlled studies in pregnant women. So Olopatadine should be used in pregnancy only if the possible benefit justifies the possible risk to the fetus.
It isn't known whether eye drops put on the surface of the eye can be absorbed into the body enough to leave detectable amounts in human breast milk. Even so, a nursing mother should take caution when using Olopatadine.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
For geriatric use of Olopatadine Hydrochloride, no overall differences in safety or effectiveness have been observed.
Overdose
There's no information available on an overdose of Olopatadine Hydrochloride. Even so, using too much of any medicine can cause serious harm, so if you think you've had an overdose, get medical help without delay.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Olopatadine Hydrochloride at room temperature and away from light. It's best not to use what is left in the bottle more than one month after you first open it.
Drug Interactions
Common questions about Opatin 665 mcg
What is Opatin 665 mcg Nasal Spray?
Opatin 665 mcg Nasal Spray is a medicine that contains Olopatadine Hydrochloride. It is made by Opsonin Pharma Limited. It belongs to the Ophthalmic Non-Steroid drugs group of medicines.
What is Opatin used for?
Opatin is used for: Allergic Rhinitis, Urticaria, Allergy, Conjunctivitis.
What are the side effects of Opatin?
Headaches have been reported with Olopatadine Hydrochloride, though rarely. Other side effects that have been reported are asthenia, blurred vision, burning or stinging, cold syndrome, dry eye, a feeling of something foreign in the eye, hyperemia, hypersensitivity, keratitis, lid edema, nausea, pharyngitis, pruritus, rhinitis, sinusitis and taste perversion.
Can I take Opatin during pregnancy or while breastfeeding?
Olopatadine did not cause birth defects (it was found not to be teratogenic) in studies on rats and rabbits. But there are no adequate and well controlled studies in pregnant women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Opatin?
There's no information available on an overdose of Olopatadine Hydrochloride. Even so, using too much of any medicine can cause serious harm, so if you think you've had an overdose, get medical help without delay. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Opatin?
Keep Olopatadine Hydrochloride at room temperature and away from light. It's best not to use what is left in the bottle more than one month after you first open it.
Can I take other medicines with Opatin?
Some medicines can interact with Olopatadine Hydrochloride, for example: Olopatadine. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Opatin?
Opatin is a prescription (Rx) medicine. Take it as your doctor advises.