Ofloxacin + Clotrimazole + Beclomethasone + Lidocaine

This ear drop combines Ofloxacin, Clotrimazole, Beclomethasone and Lidocaine, so it acts as an antibacterial, an antifungal, an anti-inflammatory and a topical local anesthetic all in one. It has been specially formulated to maintain the natural environment of the external ear canal.

Ofloxacin is a fluoroquinolone with a broad spectrum of activity against otic pathogens, and it does not cause ototoxicity. That is why Ofloxacin is preferred to Aminoglycosides for any application within the middle ear space. It works by inhibiting DNA gyrase in bacteria. Ofloxacin has been shown to be active against the following organisms responsible for otic infections. Gram-positive: Staphylococcus aureus, Streptococcus pneumoniae. Gram-negative: Escherichia coli, Haemophilus influenzae, Moraxella catarrhalis, Proteus mirabilis, Pseudomonas aeruginosa.

Clotrimazole is a synthetic imidazole derivative and a broad-spectrum antifungal agent. It has fungicidal activity against fungi that cause superficial mycotic infections of the outer or middle ear, including Candida, Microsporum & Trichophyton. Clotrimazole inhibits Cytochrome P-450 synthesis of Ergosterol, which lowers the integrity of the fungal cell wall and so stops fungal growth. It also has activity against certain bacteria such as Streptococci and Staphylococci, and this antibacterial effect is an advantage in treating mixed bacterial-fungal infections.

Beclomethasone Dipropionate is a potent steroid compared with other topical corticosteroids. Like them, it has anti-inflammatory, antipruritic and vasoconstrictive properties. It induces phospholipase A2 and sequentially inhibits the release of arachidonic acid, thereby depressing the formation, release and activity of prostaglandins, leukotrienes and other inflammatory mediators.

Lidocaine Hydrochloride is a topical local anesthetic that helps reduce pain and stinging in the ear.