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Ofloxacin + Clotrimazole + Beclomethasone + Lidocaine ear drop is used to treat superficial bacterial and fungal infections of the external auditory canal and the middle ear. It works when the infection is caused by organisms that Ofloxacin and Clotrimazole can act against.
Pharmacology
This ear drop combines Ofloxacin, Clotrimazole, Beclomethasone and Lidocaine, so it acts as an antibacterial, an antifungal, an anti-inflammatory and a topical local anesthetic all in one. It has been specially formulated to maintain the natural environment of the external ear canal.
Ofloxacin is a fluoroquinolone with a broad spectrum of activity against otic pathogens, and it does not cause ototoxicity. That is why Ofloxacin is preferred to Aminoglycosides for any application within the middle ear space. It works by inhibiting DNA gyrase in bacteria. Ofloxacin has been shown to be active against the following organisms responsible for otic infections. Gram-positive: Staphylococcus aureus, Streptococcus pneumoniae. Gram-negative: Escherichia coli, Haemophilus influenzae, Moraxella catarrhalis, Proteus mirabilis, Pseudomonas aeruginosa.
Clotrimazole is a synthetic imidazole derivative and a broad-spectrum antifungal agent. It has fungicidal activity against fungi that cause superficial mycotic infections of the outer or middle ear, including Candida, Microsporum & Trichophyton. Clotrimazole inhibits Cytochrome P-450 synthesis of Ergosterol, which lowers the integrity of the fungal cell wall and so stops fungal growth. It also has activity against certain bacteria such as Streptococci and Staphylococci, and this antibacterial effect is an advantage in treating mixed bacterial-fungal infections.
Beclomethasone Dipropionate is a potent steroid compared with other topical corticosteroids. Like them, it has anti-inflammatory, antipruritic and vasoconstrictive properties. It induces phospholipase A2 and sequentially inhibits the release of arachidonic acid, thereby depressing the formation, release and activity of prostaglandins, leukotrienes and other inflammatory mediators.
Lidocaine Hydrochloride is a topical local anesthetic that helps reduce pain and stinging in the ear.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults and children put 2 to 5 drops into the affected ear three to four times a day, for 7 to 14 days. For otitis externa with an intact tympanic membrane, this can be used from age 06 months and older. For chronic suppurative otitis media with a perforated tympanic membrane, it is for those aged 12 years and older.
To apply the drops, tilt your head to one side so the affected ear faces up. In adults and in children older than 3 years, gently pull the ear lobe up and backward. In pediatric patients, gently pull the ear lobe down and backward.
Side Effects
Systemic side effects aren't common with these ear drops. When using Ofloxacin + Clotrimazole + Beclomethasone + Lidocaine, you may notice itching, burning, irritation, dryness, earache, headache, vertigo, dizziness, redness, folliculitis, hypertrichosis, acne form eruptions and hypopigmentation.
Cautions & Contraindications
Warnings & Precautions
If there's no good response within one week, stop using Ofloxacin + Clotrimazole + Beclomethasone + Lidocaine and take cultures to guide the next step of treatment. As with other anti-infective preparations, using it for a long time may let organisms that are not susceptible overgrow. If local irritation or sensitization develops, stop the medicine and start appropriate therapy. Further evaluation is recommended if otorrhea continues after a full course of treatment, or if two or more episodes of otorrhea occur within six months. This is to exclude an underlying condition such as cholesteatoma, a foreign body or a tumor. The medicine is not for ophthalmic use and not for injection.
Contraindications
Don't use this ear drop if you are sensitive to Ofloxacin or any other quinolone, or to any of the other components in the medicine. It must also not be used when the ear has a viral infection.
Pregnancy & Breastfeeding
Nobody has established that the combination of Ofloxacin, Clotrimazole, Beclomethasone and Lidocaine is safe in pregnancy or while breastfeeding. It is also not known whether the active substances pass into breast milk when the product is applied topically. So the doctor should weigh the possible benefit of this product during pregnancy or lactation against the possible hazard to the fetus or the nursing infant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store this medicine below 25°C, and keep it away from light and moisture.
Common questions about Oflo Plus 0.3%+1%+0.025%+2%
What is Oflo Plus 0.3%+1%+0.025%+2% Ear Drop?
Oflo Plus 0.3%+1%+0.025%+2% Ear Drop is a medicine that contains Ofloxacin + Clotrimazole + Beclomethasone + Lidocaine. It is made by G. A. Company Ltd. It belongs to the 4-Quinolone preparations group of medicines.
What is Oflo Plus used for?
Ofloxacin + Clotrimazole + Beclomethasone + Lidocaine ear drop is used to treat superficial bacterial and fungal infections of the external auditory canal and the middle ear. It works when the infection is caused by organisms that Ofloxacin and Clotrimazole can act against.
What are the side effects of Oflo Plus?
Systemic side effects aren't common with these ear drops. When using Ofloxacin + Clotrimazole + Beclomethasone + Lidocaine, you may notice itching, burning, irritation, dryness, earache, headache, vertigo, dizziness, redness, folliculitis, hypertrichosis, acne form eruptions and hypopigmentation.
Can I take Oflo Plus during pregnancy or while breastfeeding?
Nobody has established that the combination of Ofloxacin, Clotrimazole, Beclomethasone and Lidocaine is safe in pregnancy or while breastfeeding. It is also not known whether the active substances pass into breast milk when the product is applied topically. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Oflo Plus?
Store this medicine below 25°C, and keep it away from light and moisture.
Do I need a prescription for Oflo Plus?
Oflo Plus is a prescription (Rx) medicine. Take it as your doctor advises.