Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Angina Pectoris

Nictoris tablet is used to help prevent angina attacks and for their ongoing, long-term management.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Nicorandil works by opening potassium channels, which relaxes the arterioles and the large coronary arteries. It also activates guanylate cyclase, an action that widens the veins. Together, these effects ease the heart's workload by lowering both preload and afterload, while also improving blood flow through the coronary arteries.

Pregnancy & Breastfeeding

During pregnancy, animal studies have not pointed to any harm to the unborn baby from Nicorandil, but the medicine has not been studied in pregnant women. If it is used during pregnancy, the expected benefit needs to be weighed against any possible risk. It is not known whether Nicorandil passes into human breast milk, so it should be used with caution in breastfeeding mothers.

Drug interactions: Studies in animals and humans have not shown a pharmacological or pharmacokinetic interaction between Nicorandil and beta-blockers, calcium channel blockers, digoxin, a digoxin and furosemide combination, rifampicin, or cimetidine. Even so, it cannot be ruled out that Nicorandil may add to the effect of other vasodilators, tricyclic antidepressants and blood pressure lowering drugs taken at the same time, particularly when combined with alcohol.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The usual dose for adults with nicorandil is 10 to 20 mg twice daily. Most people start on 10 mg twice daily, preferably once in the morning and once in the evening. The dose can then be raised, depending on the patient's needs, response and how well they tolerate it, up to 40 mg twice daily if necessary. Some people who are especially prone to headache may begin on a lower dose of 5 mg twice daily. For elderly patients there are no special dosage requirements, but as with all medicines, the lowest effective dose should be used. Doctors usually start older patients on a low dose and give nicorandil with care. Nicorandil is not recommended for children. Nicorandil should be used with caution in patients with serious hepatic dysfunction. Hepatic impairment may mean the dose needs to be reduced.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.