Indications
Naproxen Sodium is used to relieve the signs and symptoms of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendonitis, bursitis and acute gout. It is also used in the management of primary dysmenorrhea and pain.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Naproxen sodium is a non-selective NSAID, and like the others in this group it works by blocking the COX-1 and COX-2 enzymes. This lowers the production of prostaglandins. Both enzymes contribute to prostaglandin production, but they do different jobs. COX-1 is constitutively active and is found in normal tissues such as the stomach lining. COX-2 is inducible, and the prostaglandins it produces mediate pain, fever and inflammation.
The benefits of naproxen, which are its antipyretic, analgesic and anti-inflammatory effects, come from the action on COX-2. The unwanted effects, such as gastrointestinal upset and renal toxicities, are linked to COX-1.
Pregnancy & Breastfeeding
Most non-steroidal anti-inflammatory drugs can harm the fetus because of how they act in the body. In animals, Naproxen delays parturition. It has also been linked with premature closure of the ductus arteriosus and severe pulmonary hypertension in infants whose mothers took Naproxen. In the first and third trimesters, the benefits to the mother need to be weighed carefully against the possible risks to the fetus before Naproxen is used.
Small amounts of Naproxen pass into the breast milk of nursing mothers. Some authorities consider the amount too small to harm a breast-fed infant, but some manufacturers advise avoiding breast feeding while the mother is on Naproxen therapy.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.