Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 23 hours ago

Indications

Naproxen Sodium is used to relieve the signs and symptoms of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendonitis, bursitis and acute gout. It is also used in the management of primary dysmenorrhea and pain.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Naproxen sodium is a non-selective NSAID, and like the others in this group it works by blocking the COX-1 and COX-2 enzymes. This lowers the production of prostaglandins. Both enzymes contribute to prostaglandin production, but they do different jobs. COX-1 is constitutively active and is found in normal tissues such as the stomach lining. COX-2 is inducible, and the prostaglandins it produces mediate pain, fever and inflammation.

The benefits of naproxen, which are its antipyretic, analgesic and anti-inflammatory effects, come from the action on COX-2. The unwanted effects, such as gastrointestinal upset and renal toxicities, are linked to COX-1.

Pregnancy & Breastfeeding

Most non-steroidal anti-inflammatory drugs can harm the fetus because of how they act in the body. In animals, Naproxen delays parturition. It has also been linked with premature closure of the ductus arteriosus and severe pulmonary hypertension in infants whose mothers took Naproxen. In the first and third trimesters, the benefits to the mother need to be weighed carefully against the possible risks to the fetus before Naproxen is used.

Small amounts of Naproxen pass into the breast milk of nursing mothers. Some authorities consider the amount too small to harm a breast-fed infant, but some manufacturers advise avoiding breast feeding while the mother is on Naproxen therapy.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Naproxen oral preparations should be taken with water, preferably after meals. Naproxen Enteric Coated Tablet, adults: For rheumatoid arthritis, osteoarthritis and ankylosing spondylitis, the dose is 500 to 1000 mg per day, taken in two divided doses at 12-hour intervals. The usual maintenance dose is 500 mg per day, also in two divided doses at 12-hour intervals. The total daily dose of Naproxen should not go above 1000 mg, and the 12-hour gap should be kept. For acute gout, give 750 mg first, then 250 mg every 8 hours until the attack has passed. Children under 16 years are not recommended. For dysmenorrhoea, adults should take 500 mg first, followed by 250 mg at 6 to 8 hour intervals for up to 5 days, if necessary. For other uses such as analgesia and acute musculoskeletal disorders, give 500 mg first, followed by 250 mg at 6 to 8 hour intervals, if necessary. Naproxen Enteric Coated Tablet, children: Children under 16 years are not recommended. Naproxen Suspension, children: For juvenile rheumatoid arthritis, the usual dose for children over 2 years is 10 mg/kg/day, given as two divided doses at 12-hour intervals. Treatment in children under 2 years of age is not recommended. The following can be used as a guide for the suspension dose: 13 kg (29 lb), 2.5 mL b.i.d. 25 kg (55 lb), 5 mL b.i.d. 38 kg (84 lb), 7.5 mL b.i.d. Naproxen Gel: Apply 2 to 6 times a day as required. It is not recommended for use in children.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.