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Same active ingredient — pay up to 29% less
These brands contain the same active ingredient (Naproxen Sodium). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Nipoxen SR is indicated for:
Pharmacology
Naproxen sodium is a non-selective NSAID, and like the others in this group it works by blocking the COX-1 and COX-2 enzymes. This lowers the production of prostaglandins. Both enzymes contribute to prostaglandin production, but they do different jobs. COX-1 is constitutively active and is found in normal tissues such as the stomach lining. COX-2 is inducible, and the prostaglandins it produces mediate pain, fever and inflammation.
The benefits of naproxen, which are its antipyretic, analgesic and anti-inflammatory effects, come from the action on COX-2. The unwanted effects, such as gastrointestinal upset and renal toxicities, are linked to COX-1.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Naproxen oral preparations should be taken with water, preferably after meals.
Naproxen Enteric Coated Tablet, adults: For rheumatoid arthritis, osteoarthritis and ankylosing spondylitis, the dose is 500 to 1000 mg per day, taken in two divided doses at 12-hour intervals. The usual maintenance dose is 500 mg per day, also in two divided doses at 12-hour intervals. The total daily dose of Naproxen should not go above 1000 mg, and the 12-hour gap should be kept.
For acute gout, give 750 mg first, then 250 mg every 8 hours until the attack has passed. Children under 16 years are not recommended.
For dysmenorrhoea, adults should take 500 mg first, followed by 250 mg at 6 to 8 hour intervals for up to 5 days, if necessary.
For other uses such as analgesia and acute musculoskeletal disorders, give 500 mg first, followed by 250 mg at 6 to 8 hour intervals, if necessary.
Naproxen Enteric Coated Tablet, children: Children under 16 years are not recommended.
Naproxen Suspension, children: For juvenile rheumatoid arthritis, the usual dose for children over 2 years is 10 mg/kg/day, given as two divided doses at 12-hour intervals. Treatment in children under 2 years of age is not recommended. The following can be used as a guide for the suspension dose: 13 kg (29 lb), 2.5 mL b.i.d. 25 kg (55 lb), 5 mL b.i.d. 38 kg (84 lb), 7.5 mL b.i.d.
Naproxen Gel: Apply 2 to 6 times a day as required. It is not recommended for use in children.
Side Effects
The side effects reported most often with Naproxen Sodium are grouped below by the part of the body they affect. Gastrointestinal: heartburn, abdominal pain, nausea, diarrhea and dyspepsia. Central nervous system: headache, vertigo and drowsiness. Dermatological: pruritus (itching) and purpura. Cardiovascular: edema and palpitation. Others: visual disturbances and hearing disturbances.
Cautions & Contraindications
Warnings & Precautions
Renal effects: Like other non-steroidal anti-inflammatory drugs, naproxen has caused renal papillary necrosis and other abnormal kidney changes in animals when given over a long period. In humans, there have been reports of acute interstitial nephritis, hematuria, proteinuria and, occasionally, nephrotic syndrome with products containing Naproxen Sodium and with other NSAIDs since they came on the market. Naproxen Sodium and its metabolites leave the body mainly through the kidneys. So the medicine should be used with caution in patients whose kidney function is significantly impaired, and serum creatinine and/or creatinine clearance should be monitored in these patients. Take particular care if it is given to patients with a creatinine clearance of less than 20ml/min, because naproxen metabolites have been seen to accumulate in such patients. Hepatic effects: There have been a few reports of moderate to severe jaundice attributed to Naproxen Sodium.
Contraindications
Don't give Naproxen to anyone who is known to be hypersensitive to it. It should also not be given to patients who have had asthma, urticaria or allergic-type reactions after taking aspirin or other NSAIDs. Naproxen is also contraindicated for treating perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.
Pregnancy & Breastfeeding
Most non-steroidal anti-inflammatory drugs can harm the fetus because of how they act in the body. In animals, Naproxen delays parturition. It has also been linked with premature closure of the ductus arteriosus and severe pulmonary hypertension in infants whose mothers took Naproxen. In the first and third trimesters, the benefits to the mother need to be weighed carefully against the possible risks to the fetus before Naproxen is used.
Small amounts of Naproxen pass into the breast milk of nursing mothers. Some authorities consider the amount too small to harm a breast-fed infant, but some manufacturers advise avoiding breast feeding while the mother is on Naproxen therapy.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Naproxen Sodium below 30°C, away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Nipoxen SR 500 mg
What is Nipoxen SR 500 mg Tablet (Sustained Release)?
Nipoxen SR 500 mg Tablet (Sustained Release) is a medicine that contains Naproxen Sodium. It is made by NIPRO JMI Pharma Limited. It belongs to the Drugs for Osteoarthritis group of medicines.
What is Nipoxen SR used for?
Nipoxen SR is used for: Pain, Osteoarthritis, Rheumatoid Arthritis, Gout, Menstrual Disorder.
What are the side effects of Nipoxen SR?
The side effects reported most often with Naproxen Sodium are grouped below by the part of the body they affect. Gastrointestinal: heartburn, abdominal pain, nausea, diarrhea and dyspepsia.
Can I take Nipoxen SR during pregnancy or while breastfeeding?
Most non-steroidal anti-inflammatory drugs can harm the fetus because of how they act in the body. In animals, Naproxen delays parturition. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Nipoxen SR?
Store Naproxen Sodium below 30°C, away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Nipoxen SR?
Some medicines can interact with Naproxen Sodium, for example: Warfarin Sodium, Aspirin, Sucralfate, Methotrexate, Furosemide. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Naproxen SR by Zenith Pharmaceuticals Ltd. has the same ingredient and strength for ৳10.00 per unit, compared with ৳14.04 for Nipoxen SR. Ask your doctor or pharmacist before switching.
Do I need a prescription for Nipoxen SR?
Nipoxen SR is a prescription (Rx) medicine. Take it as your doctor advises.