Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago
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Indications

Osteoarthritis Rheumatoid Arthritis

Nabumetone is used to relieve the signs and symptoms of osteoarthritis and rheumatoid arthritis. Before starting it, the doctor should weigh the possible benefits and risks of Nabumetone against the other treatment options. The dose should be the lowest that works, and it should be used for the shortest time that still suits the patient's treatment goals.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Nabumetone is a non-steroidal anti-inflammatory drug (NSAID). In pharmacologic studies it has shown anti-inflammatory, pain-relieving and fever-reducing effects. As with other NSAIDs, how it works is not known, but its ability to block prostaglandin synthesis may play a part in the anti-inflammatory effect. The nabumetone you take is a prodrug. The liver converts it into the active component, 6-methoxy-2-naphthylacetic acid (6MNA), which is a potent inhibitor of prostaglandin synthesis.

Pregnancy & Breastfeeding

Nabumetone is Pregnancy Category C. There are no adequate, well-controlled studies in pregnant women, so it should be used during pregnancy only if clearly needed. Drugs that inhibit prostaglandin synthesis are known to affect the human fetal cardiovascular system (they cause closure of the ductus arteriosus). Because of this, Nabumetone is not recommended in the third trimester of pregnancy.

Lactation: Nabumetone is not recommended for nursing mothers, because prostaglandin-synthesis-inhibiting drugs may have adverse effects on neonates.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Nabumetone 500 mg and 750 mg tablets are taken by mouth. For the Nabumetone 1000 mg tablet, mix 1 tablet thoroughly in a glass (250 ml) of pure water and drink all of it. For osteoarthritis and rheumatoid arthritis, the recommended starting dose is 1000 mg as a single dose, with or without food. Some patients get more symptom relief from 1500 mg to 2000 mg per day. Nabumetone can be given once a day or as two doses a day. Doses greater than 2000 mg per day have not been studied, and for long-term treatment the lowest effective dose should be used. Doctors should be careful when prescribing Nabumetone to patients with moderate or severe renal insufficiency. In these patients the starting dose should not be more than 750 mg once daily for moderate insufficiency and 500 mg once daily for severe insufficiency. If renal function is monitored carefully, the daily dose may then be raised to a maximum of 1500 mg and 1000 mg, respectively. Safety and effectiveness of Nabumetone in children have not been established.