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Same active ingredient — pay up to 13% less
These brands contain the same active ingredient (Nabumetone). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Flamfix
Other strengths and forms by Square Pharmaceuticals PLC, Pabna
Indications & Uses
Flamfix is indicated for:
Pharmacology
Nabumetone is a non-steroidal anti-inflammatory drug (NSAID). In pharmacologic studies it has shown anti-inflammatory, pain-relieving and fever-reducing effects. As with other NSAIDs, how it works is not known, but its ability to block prostaglandin synthesis may play a part in the anti-inflammatory effect. The nabumetone you take is a prodrug. The liver converts it into the active component, 6-methoxy-2-naphthylacetic acid (6MNA), which is a potent inhibitor of prostaglandin synthesis.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Nabumetone 500 mg and 750 mg tablets are taken by mouth. For the Nabumetone 1000 mg tablet, mix 1 tablet thoroughly in a glass (250 ml) of pure water and drink all of it.
For osteoarthritis and rheumatoid arthritis, the recommended starting dose is 1000 mg as a single dose, with or without food. Some patients get more symptom relief from 1500 mg to 2000 mg per day. Nabumetone can be given once a day or as two doses a day. Doses greater than 2000 mg per day have not been studied, and for long-term treatment the lowest effective dose should be used.
Doctors should be careful when prescribing Nabumetone to patients with moderate or severe renal insufficiency. In these patients the starting dose should not be more than 750 mg once daily for moderate insufficiency and 500 mg once daily for severe insufficiency. If renal function is monitored carefully, the daily dose may then be raised to a maximum of 1500 mg and 1000 mg, respectively.
Safety and effectiveness of Nabumetone in children have not been established.
Side Effects
Nabumetone can cause the following side effects. Gastrointestinal: diarrhea, dyspepsia, abdominal pain, constipation, flatulence, nausea, positive stool guaiac, dry mouth, gastritis, stomatitis and vomiting. Central Nervous System: dizziness, headache, fatigue, increased sweating, insomnia, nervousness and somnolence. Dermatologic: pruritus and rash. Special Senses: tinnitus. Miscellaneous: edema.
Cautions & Contraindications
Warnings & Precautions
NSAIDs as a class have been linked with renal papillary necrosis and other abnormal kidney changes when given to animals over a long period. There is a second kind of kidney toxicity often seen with NSAIDs. It occurs in patients whose condition lowers renal blood flow or blood volume. In these patients, renal prostaglandins help to maintain renal perfusion, so an NSAID reduces prostaglandin synthesis in a dose-dependent way. This then reduces renal blood flow, which may bring on overt renal decompensation. The patients at greatest risk of this reaction are those with impaired renal function, heart failure or liver dysfunction, those taking diuretics, and the elderly. Discontinuation of the NSAID is usually followed by recovery to the pretreatment state.
Contraindications
Nabumetone must not be given to anyone who is known to be allergic to nabumetone or to any of the other ingredients in the tablet. It should also not be given to people who have had asthma, urticaria or allergic-type reactions after taking aspirin or another NSAID. In such patients, severe anaphylactic-like reactions to NSAIDs have been reported, and these have rarely been fatal. Nabumetone is also contraindicated for treating peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
Pregnancy & Breastfeeding
Nabumetone is Pregnancy Category C. There are no adequate, well-controlled studies in pregnant women, so it should be used during pregnancy only if clearly needed. Drugs that inhibit prostaglandin synthesis are known to affect the human fetal cardiovascular system (they cause closure of the ductus arteriosus). Because of this, Nabumetone is not recommended in the third trimester of pregnancy.
Lactation: Nabumetone is not recommended for nursing mothers, because prostaglandin-synthesis-inhibiting drugs may have adverse effects on neonates.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
After an acute NSAID overdose, the symptoms are usually limited to lethargy, drowsiness, nausea, vomiting and epigastric pain. These generally clear with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression and coma may also happen, but they are rare. Anaphylactoid reactions have been reported even with NSAIDs taken at therapeutic doses, and they may occur after an overdose too.
A patient with an NSAID overdose should be managed with symptomatic and supportive care, as there are no specific antidotes. Emesis and/or activated charcoal (60 to 100 grams in adults, 1 to 2 g/kg in children) and/or an osmotic cathartic may be indicated in patients seen within 4 hours of ingestion with symptoms, or after a large overdose (5 to 10 times the usual dose). Forced diuresis, alkalinization of urine, hemodialysis or hemoperfusion may not be useful because of the high protein binding.
Overdoses of up to 25 grams of Nabu have been reported with no long-term sequelae after standard emergency treatment (that is, activated charcoal, gastric lavage, IV H2-blockers and so on).
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Nabumetone in a cool, dry place, away from light and moisture. And keep all medicines out of children's reach.
Common questions about Flamfix 500 mg
What is Flamfix 500 mg Tablet?
Flamfix 500 mg Tablet is a medicine that contains Nabumetone. It is made by Square Pharmaceuticals PLC, Pabna. It belongs to the Drugs for Osteoarthritis group of medicines.
What is Flamfix used for?
Flamfix is used for: Osteoarthritis, Rheumatoid Arthritis.
What are the side effects of Flamfix?
Nabumetone can cause the following side effects. Gastrointestinal: diarrhea, dyspepsia, abdominal pain, constipation, flatulence, nausea, positive stool guaiac, dry mouth, gastritis, stomatitis and vomiting.
Can I take Flamfix during pregnancy or while breastfeeding?
Nabumetone is Pregnancy Category C. There are no adequate, well-controlled studies in pregnant women, so it should be used during pregnancy only if clearly needed. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Flamfix?
After an acute NSAID overdose, the symptoms are usually limited to lethargy, drowsiness, nausea, vomiting and epigastric pain. These generally clear with supportive care. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Flamfix?
Keep Nabumetone in a cool, dry place, away from light and moisture. And keep all medicines out of children's reach.
Is there a cheaper medicine with the same ingredient?
Naburel by Aristopharma Limited has the same ingredient and strength for ৳13.00 per unit, compared with ৳15.00 for Flamfix. Ask your doctor or pharmacist before switching.
Do I need a prescription for Flamfix?
Flamfix is a prescription (Rx) medicine. Take it as your doctor advises.