Indications
Trego ointment is used to treat impetigo, a skin infection caused by *Staphylococcus aureus* and *Streptococcus pyogenes*, when applied to the skin. It is also used to treat folliculitis and furunculosis.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Mupirocin is a naturally occurring antibiotic. It is made by fermentation, using the organism Pseudomonas fluorescens. It works against a wide range of bacteria, which are responsible for most skin infections. These include Staphylococcus aureus, including methicillin-resistant strains (MRSA), and Streptococcus pyogenes. It also works against certain gram-negative bacteria such as Escherichia coli and Haemophilus influenzae.
Mupirocin stops bacteria from making proteins. It does this by binding, in a reversible and specific way, to a bacterial enzyme called isoleucyl transfer-RNA synthetase. Because it acts in this unusual way, mupirocin shows no cross-resistance in laboratory tests with other classes of antimicrobial agents.
At the levels reached with topical use, mupirocin kills bacteria. However, the minimum bactericidal concentration (MBC) against relevant pathogens is usually eight-fold to thirty-fold higher than the minimum inhibitory concentration (MIC).
Pregnancy & Breastfeeding
Reproduction studies with Mupirocin ointment in animals have shown no evidence of harm to the developing baby. However, since there is no clinical experience with its use during pregnancy, it should be used only if the expected benefits are considered to outweigh any possible risks. Whether this medicine passes into human breast milk is not known. As many medicines do pass into breast milk, Mupirocin ointment should be used with caution by breastfeeding mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.