More from Systop
Other strengths and forms by Advanced Chemical Industries PLC.
Indications & Uses
Trego ointment is used to treat impetigo, a skin infection caused by *Staphylococcus aureus* and *Streptococcus pyogenes*, when applied to the skin. It is also used to treat folliculitis and furunculosis.
Pharmacology
Mupirocin is a naturally occurring antibiotic. It is made by fermentation, using the organism Pseudomonas fluorescens. It works against a wide range of bacteria, which are responsible for most skin infections. These include Staphylococcus aureus, including methicillin-resistant strains (MRSA), and Streptococcus pyogenes. It also works against certain gram-negative bacteria such as Escherichia coli and Haemophilus influenzae.
Mupirocin stops bacteria from making proteins. It does this by binding, in a reversible and specific way, to a bacterial enzyme called isoleucyl transfer-RNA synthetase. Because it acts in this unusual way, mupirocin shows no cross-resistance in laboratory tests with other classes of antimicrobial agents.
At the levels reached with topical use, mupirocin kills bacteria. However, the minimum bactericidal concentration (MBC) against relevant pathogens is usually eight-fold to thirty-fold higher than the minimum inhibitory concentration (MIC).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Apply a small amount of Mupirocin ointment to the affected area 3 times daily for up to 10 days.
Mupirocin ointment has been shown to be safe and effective in children and adolescents aged 2 months to 16 years. Its use in these age groups is supported by adequate and well-controlled studies of Mupirocin in impetigo in paediatric patients.
Side Effects
Reported side effects include a burning, stinging or painful sensation, and itching. Some patients may also experience rash, nausea, redness (erythema), dry skin, tenderness, swelling, contact dermatitis or increased discharge from the treated area.
Cautions & Contraindications
Warnings & Precautions
Trego ointment should not be used in or near the eyes or inside the nose. As with other antibacterial products, prolonged use may lead to overgrowth of non-susceptible organisms, including fungi. When applying Trego to the face, care should be taken to avoid contact with the eyes. It is not suitable for use with cannulae or at the site of central venous cannulation. If sensitization or severe local irritation occurs with Trego ointment, use should be stopped and an appropriate alternative therapy for the infection started. Trego ointment should not be mixed with other preparations, as this can dilute it, reducing its antibacterial activity and potentially affecting its stability.
Contraindications
Mupirocin should not be used by anyone who has previously had an allergic reaction to it or to any other ingredient in this preparation.
Pregnancy & Breastfeeding
Reproduction studies with Mupirocin ointment in animals have shown no evidence of harm to the developing baby. However, since there is no clinical experience with its use during pregnancy, it should be used only if the expected benefits are considered to outweigh any possible risks. Whether this medicine passes into human breast milk is not known. As many medicines do pass into breast milk, Mupirocin ointment should be used with caution by breastfeeding mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
We don't have much data on overdose with Mupirocin ointment. If an overdose happens, the patient should be treated with supportive care and monitored as needed.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Mupirocin below 25° C, away from light and moisture. Don't let it freeze. Keep it out of the reach of children.
Common questions about Systop 100 mg
What is Systop 100 mg Ointment?
Systop 100 mg Ointment is a medicine that contains Mupirocin. It is made by Advanced Chemical Industries PLC. It belongs to the Topical Antibiotic preparations group of medicines.
What is Systop used for?
Trego ointment is used to treat impetigo, a skin infection caused by *Staphylococcus aureus* and *Streptococcus pyogenes*, when applied to the skin. It is also used to treat folliculitis and furunculosis.
What are the side effects of Systop?
Reported side effects include a burning, stinging or painful sensation, and itching. Some patients may also experience rash, nausea, redness (erythema), dry skin, tenderness, swelling, contact dermatitis or increased discharge from the treated area.
Can I take Systop during pregnancy or while breastfeeding?
Reproduction studies with Mupirocin ointment in animals have shown no evidence of harm to the developing baby. However, since there is no clinical experience with its use during pregnancy, it should be used only if the expected benefits are considered to outweigh any possible risks. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Systop?
We don't have much data on overdose with Mupirocin ointment. If an overdose happens, the patient should be treated with supportive care and monitored as needed. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Systop?
Store Mupirocin below 25° C, away from light and moisture. Don't let it freeze.
Do I need a prescription for Systop?
Systop is a prescription (Rx) medicine. Take it as your doctor advises.