Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago
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Indications

Asthma Allergic Rhinitis

Montelukast Sodium is used for the prophylaxis and chronic treatment of asthma, the acute prevention of Exercise-Induced Bronchoconstriction (EIB), and the relief of symptoms of Allergic Rhinitis (AR), covering both seasonal and perennial allergic rhinitis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Montelukast is a selective leukotriene receptor antagonist that works when taken by mouth. It blocks the cysteinyl leukotriene receptor (CysLT1). The cysteinyl leukotrienes (LTC4, LTD4, LTE4) come from the metabolism of arachidonic acid, and various cells release them, including mast cells and eosinophils. Both these leukotrienes and the occupation of their receptors have been linked with the pathophysiology of asthma & allergic rhinitis. This includes airway edema, smooth muscle contraction and altered cellular activity tied to the inflammatory process, and all of these add to the signs and symptoms of asthma.

Pregnancy & Breastfeeding

Montelukast has been shown to cross the placenta in rats and rabbits after oral dosing. There are no adequate and well-controlled studies in pregnant women, though. Animal reproduction studies don't always predict how humans will respond, so Montelukast should be used during pregnancy only if it is clearly needed. Many drugs pass into human milk, so a nursing mother should be given Montelukast with caution.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adults and adolescents with asthma or seasonal allergic rhinitis: for adults and adolescents 15 years of age and older, the dose is one Montelukast 10 mg tablet once daily. Children with asthma or seasonal allergic rhinitis: for children 6 to 14 years of age, the dose is one Montelukast 5 mg tablet once daily. For children 2 years to 5 years of age, it is one Montelukast 4 mg tablet once daily. For children 6 months to 5 years of age, the dose is Montelukast 4 mg oral granules once daily. The granules can be given directly in the mouth, or mixed with a spoonful of cold water or soft food at room temperature. Use in children: the safety and efficacy of Montelukast have been established in adequate and well-controlled studies in children with asthma aged 6 months to 14 years. The safety and efficacy profiles in this age group are similar to those seen in adults. Hepatic insufficiency: no dosage adjustment is required in patients with mild-to-moderate hepatic insufficiency. Renal insufficiency: no dosage adjustment is recommended in patients with renal insufficiency. Elderly use: the pharmacokinetic profile and the oral bioavailability of a single 10-mg oral dose of montelukast are similar in elderly and younger adults. The plasma half-life of montelukast is slightly longer in the elderly. No dosage adjustment is required in the elderly.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.