Mesalazine [5-aminosalicylic acid]

Adults: Mesalazine tablet dose for treating mild to moderate Ulcerative Colitis. Adult: the recommended dosage of Mesalazine is 800 mg (two 400 mg tablets) three times daily for a duration of 6 weeks. A dose up to 4.8 g/day in divided doses may be given if needed. Child: for children 5 years of age and older, the daily dosage depends on the weight group (kg). In the 17 to <33 group, the morning dosage is two 400 mg tablets and the evening dosage is one 400 mg tablet, for a duration of 6 weeks. In the 33 to <54 group, the morning dosage is three 400 mg tablets and the evening dosage is two 400 mg tablets. For maintenance of remission of mild to moderate Ulcerative Colitis, the recommended adult dosage is 1.6 g (four 400 mg tablets) daily in two to four divided doses. A dose up to 2.4 g/day in divided doses may be given if needed. For maintenance of remission of Crohn's disease, adults take 1.2 to 2.4 g daily in divided doses. Children take 400 to 800 mg 3 times daily. Prolonged release granules dose for treating ulcerative colitis. Adults with active disease: the dosage is individual, up to 4 gm mesalazine once daily or divided into 2 to 4 doses. For maintenance treatment the dosage is also individual, and the recommended dosage is 2 gm mesalazine once daily. Pediatrics: safety and efficacy in children below 6 years of age have not been established. There is only limited documentation for an effect in children aged 6 to 18 years. For children 6 years of age and older with active disease, the dose is to be determined individually, starting with 30 to 50 mg/kg/day in divided doses. The maximum dose is 75 mg/kg/day in divided doses, and the total dose should not exceed 4 g/day (the maximum adult dose). For maintenance treatment, the dose is again determined individually, starting with 15 to 30 mg/kg/day in divided doses. The total dose should not exceed 2 g/day (the recommended adult dose). It is generally recommended that children up to a body weight of 40 kg get half the adult dose, and those above 40 kg get the normal adult dose. The granules must not be chewed. Empty the contents of the sachet onto the tongue and wash it down with some water or orange juice. Or the entire content of the sachet can be taken with yogurt and consumed immediately.