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Indications & Uses
Mesala is indicated for:
Pharmacology
Nobody knows exactly how Mesalamine works, but its action seems to be topical (on the bowel lining) rather than systemic. In people with chronic infammatory bowel disease, the lining of the gut makes more Arachidonic Acid metabolites. These are produced through the cyclooxygenase pathways, that is, prostanoids, and through the lipoxygenase pathways, that is, leukotrienes and hydroxyeicosatetraenoic acids. Mesalamine reduces infammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Mesalazine tablet dose for treating mild to moderate Ulcerative Colitis. Adult: the recommended dosage of Mesalazine is 800 mg (two 400 mg tablets) three times daily for a duration of 6 weeks. A dose up to 4.8 g/day in divided doses may be given if needed. Child: for children 5 years of age and older, the daily dosage depends on the weight group (kg). In the 17 to <33 group, the morning dosage is two 400 mg tablets and the evening dosage is one 400 mg tablet, for a duration of 6 weeks. In the 33 to <54 group, the morning dosage is three 400 mg tablets and the evening dosage is two 400 mg tablets.
For maintenance of remission of mild to moderate Ulcerative Colitis, the recommended adult dosage is 1.6 g (four 400 mg tablets) daily in two to four divided doses. A dose up to 2.4 g/day in divided doses may be given if needed.
For maintenance of remission of Crohn's disease, adults take 1.2 to 2.4 g daily in divided doses. Children take 400 to 800 mg 3 times daily.
Prolonged release granules dose for treating ulcerative colitis. Adults with active disease: the dosage is individual, up to 4 gm mesalazine once daily or divided into 2 to 4 doses. For maintenance treatment the dosage is also individual, and the recommended dosage is 2 gm mesalazine once daily.
Pediatrics: safety and efficacy in children below 6 years of age have not been established. There is only limited documentation for an effect in children aged 6 to 18 years. For children 6 years of age and older with active disease, the dose is to be determined individually, starting with 30 to 50 mg/kg/day in divided doses. The maximum dose is 75 mg/kg/day in divided doses, and the total dose should not exceed 4 g/day (the maximum adult dose). For maintenance treatment, the dose is again determined individually, starting with 15 to 30 mg/kg/day in divided doses. The total dose should not exceed 2 g/day (the recommended adult dose). It is generally recommended that children up to a body weight of 40 kg get half the adult dose, and those above 40 kg get the normal adult dose.
The granules must not be chewed. Empty the contents of the sachet onto the tongue and wash it down with some water or orange juice. Or the entire content of the sachet can be taken with yogurt and consumed immediately.
Side Effects
People taking mesalazine most often report headache, nausea, dizziness, weakness, indigestion, vomiting and itching, among a few other effects.
Cautions & Contraindications
Warnings & Precautions
Patients with pyloric stenosis may hold Mesalamine tablets in the stomach for longer than usual, and this could delay the release of Mesalamine in the colon. Renal impairment has been reported in people taking Mesalamine. This includes minimal change nephropathy and acute and chronic interstitial nephritis. So caution is needed when Mesalamine is used in patients with known renal dysfunction or a history of renal disease. Renal function should be checked before treatment starts and then monitored from time to time during treatment. There have also been reports of hepatic failure in patients with pre-existing liver disease who were given Mesalamine. Take care when giving Mesalamine to patients with liver impairment.
Contraindications
Don't use mesalazine if you are hypersensitive to salicylates or to any other component of the formulation.
Pregnancy & Breastfeeding
Mesalazine should be given during pregnancy only when the expected benefit is greater than the possible risk to the baby. Take care when it is given to a breastfeeding mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Geriatrics: if a patient is 65 years or older, watch the blood cell counts closely during Mesalamine therapy.
Elderly: older patients are more likely to have reduced kidney function, so take care when prescribing Mesalazine [5-aminosalicylic acid]. Every patient should have their renal function checked before Mesalamine tablets are started. Blood cell counts should be monitored while the patient is on the medicine.
Paediatric: safety and effectiveness have not been established.
Overdose
There is no specific antidote for a Mesalamine overdose. If acute severe toxicity is suspected, treatment should be symptomatic and supportive. This may mean preventing further absorption from the gastrointestinal tract, correcting any fluid and electrolyte imbalance, and maintaining adequate renal function. Mesalamine here is a pH dependent delayed-release product, so doctors should keep that in mind when treating a suspected overdose.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Mesalazine below 30 0 C. Protect it from light and moisture. Keep all medicines out of the reach of children.
Drug Interactions
Common questions about Mesala 400 mg
What is Mesala 400 mg Tablet (Delayed Release)?
Mesala 400 mg Tablet (Delayed Release) is a medicine that contains Mesalazine [5-aminosalicylic acid]. It is made by NIPRO JMI Pharma Limited. It belongs to the Aminosalicylates group of medicines.
What is Mesala used for?
Mesala is used for: Inflammatory Bowel Disease.
What are the side effects of Mesala?
People taking mesalazine most often report headache, nausea, dizziness, weakness, indigestion, vomiting and itching, among a few other effects.
Can I take Mesala during pregnancy or while breastfeeding?
Mesalazine should be given during pregnancy only when the expected benefit is greater than the possible risk to the baby. Take care when it is given to a breastfeeding mother. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Mesala?
There is no specific antidote for a Mesalamine overdose. If acute severe toxicity is suspected, treatment should be symptomatic and supportive. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Mesala?
Store Mesalazine below 30 0 C. Protect it from light and moisture.
Can I take other medicines with Mesala?
Some medicines can interact with Mesalazine [5-aminosalicylic acid], for example: Azathioprine. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Mesala is already among the lowest-priced brands of Mesalazine [5-aminosalicylic acid] at this strength.
Do I need a prescription for Mesala?
Mesala is a prescription (Rx) medicine. Take it as your doctor advises.