Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago

Meclizine + Pyridoxine

Anti-emetic drugs Prescription
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Indications

Vertigo Nausea and Vomiting

Meclizine + Pyridoxine is used to prevent and treat nausea, vomiting, dizziness, motion sickness and radiation sickness. It is also used for vertigo that comes from diseases of the vestibular system, such as Meniere's syndrome, labyrinthitis and other vestibular disturbances.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Meclizine is a piperazine-derivative antihistamine, and it is used as an antiemetic. It has antiemetic, anticholinergic and antihistaminic properties, and it reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), through peripheral nerve pathways, through the VC itself, or through other CNS centers.

Pyridoxine is vitamin B-6. It has been added to enhance the anti-emetic effects of meclizine and as a dietary supplement.

Pregnancy & Breastfeeding

Meclizine with Pyridoxine is Pregnancy Category B. Large-scale human studies have not shown any harmful effects on the baby. Based on the data available, it has been suggested that meclizine carries the lowest risk of causing birth defects, which makes it the first-choice medicine for nausea and vomiting in pregnancy. For a nursing mother, though, safety has not been established.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adults and children aged 12 years and over can take Meclizine + Pyridoxine as follows. For nausea and vomiting, the dose is 25-50 mg daily, or as directed by a physician. For motion sickness, take a first dose of 25-50 mg, 1 hour before travel. The dose can be repeated every 24 hours for as long as the journey lasts. For radiation sickness, the dose is 50 mg, given 2-12 hours before radiation treatment. For vertigo, the dose is 25-100 mg daily, divided into smaller doses through the day. To prevent nausea and vomiting linked with the emergency contraceptive pill (ECP), take 25-50 mg 1 hour before the first ECP dose. If needed, repeat it after 24 hours. Safety and efficacy in children under 12 years of age have not been established.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.

Key Interactions

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